MicroRNAs: the fine-tuners of Toll-like receptor signalling - PubMed (original) (raw)
Review
doi: 10.1038/nri2957. Epub 2011 Feb 18.
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- PMID: 21331081
- DOI: 10.1038/nri2957
Review
MicroRNAs: the fine-tuners of Toll-like receptor signalling
Luke A O'Neill et al. Nat Rev Immunol. 2011 Mar.
Abstract
Toll-like receptor (TLR) signalling must be tightly regulated to avoid excessive inflammation and to allow for tissue repair and the return to homeostasis after infection and tissue injury. MicroRNAs (miRNAs) have emerged as important controllers of TLR signalling. Several miRNAs are induced by TLR activation in innate immune cells and these and other miRNAs target the 3' untranslated regions of mRNAs encoding components of the TLR signalling system. miRNAs are also proving to be an important link between the innate and adaptive immune systems, and their dysregulation might have a role in the pathogenesis of inflammatory diseases.
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References
- J Immunol. 2009 Apr 15;182(8):4994-5002 - PubMed
- J Autoimmun. 2009 May-Jun;32(3-4):189-94 - PubMed
- Immunity. 2007 Dec;27(6):847-59 - PubMed
- Exp Hematol. 2003 Dec;31(12):1170-81 - PubMed
- Blood. 2009 Aug 13;114(7):1374-82 - PubMed
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