The pleiotropic structure of the genotype-phenotype map: the evolvability of complex organisms - PubMed (original) (raw)
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doi: 10.1038/nrg2949.
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- PMID: 21331091
- DOI: 10.1038/nrg2949
Review
The pleiotropic structure of the genotype-phenotype map: the evolvability of complex organisms
Günter P Wagner et al. Nat Rev Genet. 2011 Mar.
Abstract
It was first noticed 100 years ago that mutations tend to affect more than one phenotypic characteristic, a phenomenon that was called 'pleiotropy'. Because pleiotropy was found so frequently, the notion arose that pleiotropy is 'universal'. However, quantitative estimates of pleiotropy have not been available until recently. These estimates show that pleiotropy is highly restricted and are more in line with the notion of variational modularity than with universal pleiotropy. This finding has major implications for the evolvability of complex organisms and the mapping of disease-causing mutations.
Comment in
- Assessing pleiotropy and its evolutionary consequences: pleiotropy is not necessarily limited, nor need it hinder the evolution of complexity.
Hill WG, Zhang XS. Hill WG, et al. Nat Rev Genet. 2012 Feb 21;13(4):296; author reply 296. doi: 10.1038/nrg2949-c1. Nat Rev Genet. 2012. PMID: 22349131 No abstract available.
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