Structural basis of signal-sequence recognition by the signal recognition particle - PubMed (original) (raw)

doi: 10.1038/nsmb.1994. Epub 2011 Feb 20.

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• PMID: 21336278
• DOI: 10.1038/nsmb.1994

Structural basis of signal-sequence recognition by the signal recognition particle

Tobias Hainzl et al. Nat Struct Mol Biol. 2011 Mar.

Abstract

The signal recognition particle (SRP) recognizes and binds the signal sequence of nascent proteins as they emerge from the ribosome. We present here the 3.0-Å structure of a signal sequence bound to the Methanococcus jannaschii SRP core. Structural comparison with the free SRP core shows that signal-sequence binding induces formation of the GM-linker helix and a 180° flip of the NG domain-structural changes that ensure a hierarchical succession of events during protein targeting.

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