Outbreak of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in France - PubMed (original) (raw)

Outbreak of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in France

Gaelle Cuzon et al. Antimicrob Agents Chemother. 2011 May.

Abstract

Seventeen Klebsiella pneumoniae isolates producing the OXA-48 carbapenemase, obtained from 10 patients hospitalized from April to June 2010, mostly in the medical intensive care unit of the Villeneuve-Saint-Georges Hospital in a suburb of Paris, France, were analyzed. Seven patients were infected, of whom five were treated at least with a carbapenem, and five patients died. Molecular analysis showed that the isolates belonged to a single clone that harbored a 70-kb plasmid carrying the blaOXA-48 gene and coproduced CTX-M-15 and TEM-1 β-lactamases. This is the first reported outbreak of OXA-48-producing K. pneumoniae isolates in France.

PubMed Disclaimer

Figures

Fig. 1.

Schematic representation of Tn_1999.2_, identified with the bla_OXA-48 gene in the epidemic clone. Genes and their transcription orientations are represented as horizontal arrows. Black triangles represent inverted repeats of insertion sequence IS_1999, and gray triangles represent inverted repeats of insertion sequence IS_1R_. Target site duplications are indicated below the sequence. Δ indicates that the gene/element is interrupted by an insertion element.

Similar articles

• Multi-drug carbapenem-resistant Klebsiella pneumoniae infection carrying the OXA-48 gene and showing variations in outer membrane protein 36 causing an outbreak in a tertiary care hospital in Riyadh, Saudi Arabia.
  Uz Zaman T, Aldrees M, Al Johani SM, Alrodayyan M, Aldughashem FA, Balkhy HH. Uz Zaman T, et al. Int J Infect Dis. 2014 Nov;28:186-92. doi: 10.1016/j.ijid.2014.05.021. Epub 2014 Sep 19. Int J Infect Dis. 2014. PMID: 25245001
• Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey.
  Carrër A, Poirel L, Eraksoy H, Cagatay AA, Badur S, Nordmann P. Carrër A, et al. Antimicrob Agents Chemother. 2008 Aug;52(8):2950-4. doi: 10.1128/AAC.01672-07. Epub 2008 Jun 2. Antimicrob Agents Chemother. 2008. PMID: 18519712 Free PMC article.
• Whole genome sequencing characterization of Slovenian carbapenem-resistant Klebsiella pneumoniae, including OXA-48 and NDM-1 producing outbreak isolates.
  Benulič K, Pirš M, Couto N, Chlebowicz M, Rossen JWA, Zorec TM, Seme K, Poljak M, Lejko Zupanc T, Ružić-Sabljić E, Cerar T. Benulič K, et al. PLoS One. 2020 Apr 13;15(4):e0231503. doi: 10.1371/journal.pone.0231503. eCollection 2020. PLoS One. 2020. PMID: 32282829 Free PMC article.
• Characterization of Isolates Associated with Emergence of OXA-48-Producing Klebsiella pneumoniae in Croatia.
  Jelić M, Škrlin J, Bejuk D, Košćak I, Butić I, Gužvinec M, Tambić-Andrašević A. Jelić M, et al. Microb Drug Resist. 2018 Sep;24(7):973-979. doi: 10.1089/mdr.2017.0168. Epub 2017 Dec 21. Microb Drug Resist. 2018. PMID: 29267137
• Clonal Dissemination of OXA-232 Carbapenemase-Producing Klebsiella pneumoniae in Neonates.
  Yin D, Dong D, Li K, Zhang L, Liang J, Yang Y, Wu N, Bao Y, Wang C, Hu F. Yin D, et al. Antimicrob Agents Chemother. 2017 Jul 25;61(8):e00385-17. doi: 10.1128/AAC.00385-17. Print 2017 Aug. Antimicrob Agents Chemother. 2017. PMID: 28533245 Free PMC article.

Cited by

• Molecular detection of OXA-48 and NDM-1 carbapenemase genes among clinical isolates of Klebsiella pneumoniae recovered from patients attending a private tertiary hospital in Southwestern Nigeria.
  Onyeji CB, Enitan SS, Kemiki OA, Igwe AC, Adeniyi AA, Iduh MU, Itodo GE, Okuneye AO, Adamson PO, Kolawole MF. Onyeji CB, et al. BMC Infect Dis. 2024 Sep 13;24(1):970. doi: 10.1186/s12879-024-09869-x. BMC Infect Dis. 2024. PMID: 39271986 Free PMC article.
• The Effect of Antibiotics on the Eradication of Multidrug-Resistant Organisms in Intestinal Carriers-A Systematic Review with Meta-Analysis.
  Knudsen MJS, Rubin IMC, Petersen AM. Knudsen MJS, et al. Antibiotics (Basel). 2024 Aug 9;13(8):747. doi: 10.3390/antibiotics13080747. Antibiotics (Basel). 2024. PMID: 39200047 Free PMC article. Review.
• Effect of biogenic bismuth nanoparticle on the expression of New Delhi metallo-β-lactamase (NDM) gene in Multidrug-Resistant Klebsiella pneumoniae.
  Sadeghi Dousari A, Shakibaie M, Hosseini-Nave H, Forootanfar H. Sadeghi Dousari A, et al. Heliyon. 2024 Jun 6;10(12):e32549. doi: 10.1016/j.heliyon.2024.e32549. eCollection 2024 Jun 30. Heliyon. 2024. PMID: 39183861 Free PMC article.
• Testing the mutant selection window hypothesis with meropenem: In vitro model study with OXA-48-producing Klebsiella pneumoniae.
  Alieva KN, Golikova MV, Dovzhenko SA, Kobrin MB, Strukova EN, Ageevets VA, Avdeeva AA, Sulian OS, Sidorenko SV, Zinner SH. Alieva KN, et al. PLoS One. 2023 Aug 4;18(8):e0288660. doi: 10.1371/journal.pone.0288660. eCollection 2023. PLoS One. 2023. PMID: 37540701 Free PMC article.
• First Isolates of OXA-48-Like Carbapenemase-Producing Enterobacteriaceae in A Specialized Cancer Center.
  Villanueva-Cotrina F, Condori DM, Gomez TO, Yactayo KM, Barron-Pastor H. Villanueva-Cotrina F, et al. Infect Chemother. 2022 Dec;54(4):765-773. doi: 10.3947/ic.2022.0135. Infect Chemother. 2022. PMID: 36596684 Free PMC article.

References

1. 1. Aktas Z., et al. 2008. Carbapenem-hydrolyzing oxacillinase OXA-48 persists in Klebsiella pneumoniae in Istanbul, Turkey. Chemotherapy 54:101–106 - PubMed
2. 1. Aubert D., Naas T., Héritier C., Poirel L., Nordmann P. 2006. Functional characterization of IS1999, an IS4 family element involved in mobilization and expression of β-lactam resistance genes. J. Bacteriol. 188:6506–6514 - PMC - PubMed
3. 1. Bell J. M., Mathai D., Jones R. N., Turnidge J. D. 2010. Emergence of OXA-48 carbapenemases among Klebsiella spp. from India, abstr. C2-650. Abstr. 50th Intersci. Conf. Antimicrob. Agents Chemother American Society for Microbiology, Washington, DC
4. 1. Benouda A., Touzani O., Khairallah M. T., Araj G. F., Matar G. M. 2010. First detection of oxacillinase-mediated resistance to carbapenems in Klebsiella pneumoniae from Morocco. Ann. Trop. Med. Parasitol. 104:327–330 - PubMed
5. 1. Castanheira M., Watters A. A., Smayevsky J., Casellas J. M., Gur D., Jones J. 2010. Emergence of blaOXA-48 among Enterobacter cloacae (ECL) in Argentina and its prevalence among carbapenem (CARB) non-susceptible (NS) Enterobacteriaceae, abstr. C2-647. Abstr. 50th Intersci. Conf. Antimicrob. Agents Chemother American Society for Microbiology, Washington, DC

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Europe PubMed Central
  • PubMed Central

• Miscellaneous

  • NCI CPTAC Assay Portal