Activin/nodal signaling and pluripotency - PubMed (original) (raw)
Review
Activin/nodal signaling and pluripotency
Zhenzhi Chng et al. Vitam Horm. 2011.
Abstract
Maintenance of a pluripotent cell population during mammalian embryogenesis is crucial for the proper generation of extraembryonic and embryonic tissues to ensure intrauterine survival and fetal development. Pluripotent stem cells derived from early stage mammalian embryos are known as "embryonic stem cells." Such embryo-derived stem cells can proliferate indefinitely in vitro and give rise to derivatives of all three primary germ layers. Their potential for clinical and commercial applications has sparked great excitement within scientific and lay communities. Identification of the signaling pathways controlling stem cell pluripotency and differentiation provides knowledge-based approaches to manipulate stem cells for regenerative medicine. One of the signaling cascades that has been identified in the control of stem cell pluripotency and differentiation is the Activin/Nodal pathway. Here, we describe the differences among pluripotent cell types and discuss the latest findings on the molecular mechanisms involving Activin/Nodal signaling in controlling their pluripotency and differentiation.
Copyright © 2011 Elsevier Inc. All rights reserved.
Similar articles
- Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells.
Vallier L, Alexander M, Pedersen RA. Vallier L, et al. J Cell Sci. 2005 Oct 1;118(Pt 19):4495-509. doi: 10.1242/jcs.02553. J Cell Sci. 2005. PMID: 16179608 - Combinatorial signals of activin/nodal and bone morphogenic protein regulate the early lineage segregation of human embryonic stem cells.
Wu Z, Zhang W, Chen G, Cheng L, Liao J, Jia N, Gao Y, Dai H, Yuan J, Cheng L, Xiao L. Wu Z, et al. J Biol Chem. 2008 Sep 5;283(36):24991-5002. doi: 10.1074/jbc.M803893200. Epub 2008 Jul 2. J Biol Chem. 2008. PMID: 18596037 Free PMC article. - TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells.
James D, Levine AJ, Besser D, Hemmati-Brivanlou A. James D, et al. Development. 2005 Mar;132(6):1273-82. doi: 10.1242/dev.01706. Epub 2005 Feb 9. Development. 2005. PMID: 15703277 - The role of activin/nodal and Wnt signaling in endoderm formation.
Payne C, King J, Hay D. Payne C, et al. Vitam Horm. 2011;85:207-16. doi: 10.1016/B978-0-12-385961-7.00010-X. Vitam Horm. 2011. PMID: 21353882 Review. - Activin/Nodal signalling in stem cells.
Pauklin S, Vallier L. Pauklin S, et al. Development. 2015 Feb 15;142(4):607-19. doi: 10.1242/dev.091769. Development. 2015. PMID: 25670788 Review.
Cited by
- Model systems for studying trophoblast differentiation from human pluripotent stem cells.
Ezashi T, Telugu BP, Roberts RM. Ezashi T, et al. Cell Tissue Res. 2012 Sep;349(3):809-24. doi: 10.1007/s00441-012-1371-2. Epub 2012 Mar 17. Cell Tissue Res. 2012. PMID: 22427062 Free PMC article. Review. - Activin-A co-opts IRF4 and AhR signaling to induce human regulatory T cells that restrain asthmatic responses.
Tousa S, Semitekolou M, Morianos I, Banos A, Trochoutsou AI, Brodie TM, Poulos N, Samitas K, Kapasa M, Konstantopoulos D, Paraskevopoulos G, Gaga M, Hawrylowicz CM, Sallusto F, Xanthou G. Tousa S, et al. Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):E2891-E2900. doi: 10.1073/pnas.1616942114. Epub 2017 Mar 20. Proc Natl Acad Sci U S A. 2017. PMID: 28320933 Free PMC article. - Proteomics and pluripotency.
Brumbaugh J, Rose CM, Phanstiel DH, Thomson JA, Coon JJ. Brumbaugh J, et al. Crit Rev Biochem Mol Biol. 2011 Dec;46(6):493-506. doi: 10.3109/10409238.2011.624491. Epub 2011 Oct 15. Crit Rev Biochem Mol Biol. 2011. PMID: 21999516 Free PMC article. Review. - Heparinized Gelatin-Based Hydrogels for Differentiation of Induced Pluripotent Stem Cells.
Arkenberg MR, Koehler K, Lin CC. Arkenberg MR, et al. Biomacromolecules. 2022 Oct 10;23(10):4141-4152. doi: 10.1021/acs.biomac.2c00585. Epub 2022 Sep 8. Biomacromolecules. 2022. PMID: 36074748 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources