Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor - PubMed (original) (raw)
Comparative Study
. 1990 Jan 25;343(6256):336-40.
doi: 10.1038/343336a0.
Affiliations
- PMID: 2137200
- DOI: 10.1038/343336a0
Comparative Study
Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor
C H Hannum et al. Nature. 1990.
Abstract
Three interleukin-1 inhibitors have been purified to homogeneity from medium conditioned by human monocytes. Partial sequence analysis and digestion with N-glycanase indicate that these are glycosylation forms of a single protein. The protein binds to the interleukin-1 receptor but has no interleukin-1-like activity, even at very high concentrations, and is therefore a pure receptor antagonist.
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