Antigen presentation requires transport of MHC class I molecules from the endoplasmic reticulum - PubMed (original) (raw)
. 1990 Feb 9;247(4943):715-8.
doi: 10.1126/science.2137259.
Affiliations
- PMID: 2137259
- DOI: 10.1126/science.2137259
Antigen presentation requires transport of MHC class I molecules from the endoplasmic reticulum
J H Cox et al. Science. 1990.
Abstract
The role of exocytosis of major histocompatibility complex (MHC) class I molecules in the presentation of antigens to mouse cytotoxic T lymphocytes (CTLs) was examined by use of a recombinant vaccinia virus that expresses the E19 glycoprotein from adenovirus. E19 blocked the presentation of vaccinia and influenza virus proteins to CTLs in a MHC class I allele-specific manner identical to its inhibition of MHC class I transport from the endoplasmic reticulum. This finding indicates that (i) the relevant parameter for antigen presentation is the rate of MHC class I molecule exocytosis, not the level of class I cell surface expression, and (ii) association of class I molecules with antigen is likely to occur within the endoplasmic reticulum.
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