IL-1 and its receptor are translocated to the nucleus - PubMed (original) (raw)
. 1990 Feb 15;144(4):1295-303.
Affiliations
- PMID: 2137488
IL-1 and its receptor are translocated to the nucleus
B M Curtis et al. J Immunol. 1990.
Abstract
The internalization and intracellular transport of IL-1 and its receptor were examined in the murine T cell line EL-4. For 4 h after internalization intracellular 125I-IL-1 alpha remains bound to its receptor without degradation. Electron microscope autoradiography demonstrates that internalized IL-1 accumulates in purified nuclei. The IL-1 extracted from these nuclei is still bound to receptor. As no receptors for IL-1 were detected in untreated nuclei, these results suggest IL-1 driven translocation of the cell surface IL-1R complex to the nucleus. IL-1R internalization was correlated with IL-1 signal transduction events required to induce growth factor production from several subclones of EL-4 cells. The subsequent transport of the internalized IL-1R complex to the nucleus suggests the possibility for a nuclear site for IL-1R signaling.
Similar articles
- The interleukin 1 receptor. Dynamics of interleukin 1 binding and internalization in T cells and fibroblasts.
Mizel SB, Kilian PL, Lewis JC, Paganelli KA, Chizzonite RA. Mizel SB, et al. J Immunol. 1987 May 1;138(9):2906-12. J Immunol. 1987. PMID: 2952728 - IL-1 and IL-4 modulate IL-1 receptor expression in a murine T cell line.
Lacey DL, Erdmann JM. Lacey DL, et al. J Immunol. 1990 Dec 15;145(12):4145-53. J Immunol. 1990. PMID: 2147936 - Interleukin 1 alpha and interleukin 1 beta bind to the same receptor on T cells.
Kilian PL, Kaffka KL, Stern AS, Woehle D, Benjamin WR, Dechiara TM, Gubler U, Farrar JJ, Mizel SB, Lomedico PT. Kilian PL, et al. J Immunol. 1986 Jun 15;136(12):4509-14. J Immunol. 1986. PMID: 2940296 - Interleukin-1 and its receptor.
Dinarello CA, Savage N. Dinarello CA, et al. Crit Rev Immunol. 1989;9(1):1-20. Crit Rev Immunol. 1989. PMID: 2523282 Review. - [Function, molecular structure and gene expression of interleukin-1].
Kasahara T, Kuno K, Matsushima K. Kasahara T, et al. Nihon Rinsho. 1992 Aug;50(8):1769-75. Nihon Rinsho. 1992. PMID: 1433966 Review. Japanese.
Cited by
- Akkermansia muciniphila induces slow extramedullary hematopoiesis via cooperative IL-1R/TLR signals.
Wang Y, Morishima T, Sezaki M, Sato R, Nakato G, Fukuda S, Kobiyama K, Ishii KJ, Li Y, Takizawa H. Wang Y, et al. EMBO Rep. 2023 Dec 6;24(12):e57485. doi: 10.15252/embr.202357485. Epub 2023 Oct 23. EMBO Rep. 2023. PMID: 37870318 Free PMC article. - Interleukin-1 receptor antagonist: a promising cytokine against human squamous cell carcinomas.
Ding Y, Yi J, Wang J, Sun Z. Ding Y, et al. Heliyon. 2023 Mar 28;9(4):e14960. doi: 10.1016/j.heliyon.2023.e14960. eCollection 2023 Apr. Heliyon. 2023. PMID: 37025835 Free PMC article. Review. - S100A8/S100A9 cytokine acts as a transcriptional coactivator during breast cellular transformation.
Song R, Struhl K. Song R, et al. Sci Adv. 2021 Jan 1;7(1):eabe5357. doi: 10.1126/sciadv.abe5357. Print 2021 Jan. Sci Adv. 2021. PMID: 33523865 Free PMC article. - IL-36 Signaling in the Tumor Microenvironment.
Chelvanambi M, Weinstein AM, Storkus WJ. Chelvanambi M, et al. Adv Exp Med Biol. 2020;1240:95-110. doi: 10.1007/978-3-030-38315-2_8. Adv Exp Med Biol. 2020. PMID: 32060891 Free PMC article. Review. - Model Predicts That MKP1 and TAB1 Regulate p38α Nuclear Pulse and Its Basal Activity through Positive and Negative Feedback Loops in Response to IL-1.
Singh R. Singh R. PLoS One. 2016 Jun 17;11(6):e0157572. doi: 10.1371/journal.pone.0157572. eCollection 2016. PLoS One. 2016. PMID: 27314954 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Research Materials