Exocytosis at the hair cell ribbon synapse apparently operates without neuronal SNARE proteins - PubMed (original) (raw)

doi: 10.1038/nn.2774. Epub 2011 Mar 6.

Affiliations

Exocytosis at the hair cell ribbon synapse apparently operates without neuronal SNARE proteins

Régis Nouvian et al. Nat Neurosci. 2011 Apr.

Abstract

SNARE proteins mediate membrane fusion. Neurosecretion depends on neuronal soluble NSF attachment protein receptors (SNAREs; SNAP-25, syntaxin-1, and synaptobrevin-1 or synaptobrevin-2) and is blocked by neurotoxin-mediated cleavage or genetic ablation. We found that exocytosis in mouse inner hair cells (IHCs) was insensitive to neurotoxins and genetic ablation of neuronal SNAREs. mRNA, but no synaptically localized protein, of neuronal SNAREs was present in IHCs. Thus, IHC exocytosis is unconventional and may operate independently of neuronal SNAREs.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Physiol Rev. 2000 Apr;80(2):717-66 - PubMed
    1. Nature. 1998 Jul 9;394(6689):192-5 - PubMed
    1. Cell. 2006 Oct 20;127(2):277-89 - PubMed
    1. Nature. 2005 Apr 14;434(7035):889-94 - PubMed
    1. Science. 2005 Jul 15;309(5733):491-4 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources