Qualitative features of the HIV-specific CD8+ T-cell response associated with immunologic control - PubMed (original) (raw)

Review

Qualitative features of the HIV-specific CD8+ T-cell response associated with immunologic control

Adam R Hersperger et al. Curr Opin HIV AIDS. 2011 May.

Abstract

Purpose of review: Over the past 2 years, a clearer picture has emerged regarding the properties of HIV-specific CD8+ T cells associated with immunologic control of HIV replication. These properties represent a potential mechanism by which rare patients might control HIV replication in the absence of antiretroviral therapy. This review addresses the background and recent findings that have lead to our current understanding of these mechanism(s).

Recent findings: Patients with immunologic control of HIV are not distinguished by targeted specificities, or greater numbers or breadth of their HIV-specific CD8+ T-cell response. For this reason, recent work has focused greater attention on qualitative features of this response. The qualitative features most closely associated with immunologic control of HIV are related to the granule-exocytosis-mediated elimination of HIV-infected CD4 T cells. The ability of HIV-specific CD8+ T cells to increase their contents of proteins known to mediate cytotoxicity, such as granzyme B and perforin, appears to be a critical means by which HIV-specific cytotoxic capacity is regulated.

Summary: Investigation from multiple groups has now focused upon HIV-specific CD8+ T-cell granule-exocytosis-mediated cytotoxicity as a correlate of immunologic control of HIV. In the near future, a more detailed understanding of the qualities associated with immunologic control may provide critical insights regarding the necessary features of a response that should be stimulated by immunotherapies or T-cell-based vaccines.

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References

    1. Migueles SA, Connors M. Long-term nonprogressive disease among untreated HIV-infected individuals: clinical implications of understanding immune control of HIV. JAMA. 2010;304:194–201. - PubMed
    1. Lopez Bernaldo de Quiros JC, Shupert WL, McNeil AC, Gea-Banacloche JC, Flanigan M, Savage A, Martino L, Weiskopf EE, Immamichi H, Zhang YM, et al. Resistance to Replication of HIV Challenge Virus in SCID-Hu Mice Engrafted with PBMC of Nonprogressors is Mediated by CD8+ T cells and Associated with a Proliferative Response to p24 Antigen. Journal of Virology. 2000;74:2023–2028. - PMC - PubMed
    1. Rabi SA, O’Connell KA, Nikolaeva D, Bailey JR, Jilek BL, Shen L, Page KR, Siliciano RF, Blankson JN. Unstimulated Primary CD4+ T Cells from HIV Type 1 Positive Elite Suppressors are Fully Susceptible to HIV-1 Entry and Productive Infection. J Virol. 2010 - PMC - PubMed
    1. Julg B, Pereyra F, Buzon MJ, Piechocka-Trocha A, Clark MJ, Baker BM, Lian J, Miura T, Martinez-Picado J, Addo MM, et al. Infrequent recovery of HIV from but robust exogenous infection of activated CD4(+) T cells in HIV elite controllers. Clin Infect Dis. 2010;51:233–238. - PMC - PubMed
    1. Blankson JN, Bailey JR, Thayil S, Yang HC, Lassen K, Lai J, Gandhi SK, Siliciano JD, Williams TM, Siliciano RF. Isolation and characterization of replication-competent human immunodeficiency virus type 1 from a subset of elite suppressors. J Virol. 2007;81:2508–2518. - PMC - PubMed

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