Low T-cell responsiveness to activation via CD3/TCR is a prognostic marker for acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus-1 (HIV-1)-infected men - PubMed (original) (raw)

Low T-cell responsiveness to activation via CD3/TCR is a prognostic marker for acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus-1 (HIV-1)-infected men

P T Schellekens et al. J Clin Immunol. 1990 Mar.

Abstract

In a cohort of 300 HIV-1-infected homosexual men, studied longitudinally, the prognostic value of T-cell proliferative responses for development of AIDS was analyzed. In 15 persons we observed that, at seroconversion, T-cell reactivity to anti-CD3 monoclonal antibody (Mab) and phytohemagglutinin (PHA) was decreased to 20 and 60% of the normal values, respectively. After seroconversion, within 3 months, the response to anti-CD3 Mab and PHA returned to 60 and 80%, respectively, of the normal magnitude and declined thereafter. To investigate whether low T-cell reactivity correlated with progression to AIDS, groups of progressors and nonprogressors were compared. In individuals who progressed to AIDS, already 12 months before diagnosis, responses to anti-CD3 Mab were virtually absent, whereas at that time CD4+ cell numbers and reactivity to horse anti-human lymphocyte serum and PHA were still comparable to values observed for nonprogressors and the asymptomatic population as a whole. In a disease-free survival analysis, low anti-CD3 Mab reactivity predicted progression to AIDS. Our findings demonstrate that low T-cell responsiveness to anti-CD3 Mab is an early marker of progression toward AIDS in HIV-1 infected individuals.

PubMed Disclaimer

Cited by

T cell receptor signaling pathway is overexpressed in CD4(+) T cells from HAM/TSP individuals.
Pinto MT, Malta TM, Rodrigues ES, Takayanagui OM, Tanaka Y, Covas DT, Kashima S. Pinto MT, et al. Braz J Infect Dis. 2015 Nov-Dec;19(6):578-84. doi: 10.1016/j.bjid.2015.07.008. Epub 2015 Sep 8. Braz J Infect Dis. 2015. PMID: 26358743 Free PMC article.
In vitro naïve T cell proliferation failure predicts poor post-immunization responses to neoantigen, but not recall antigens, in HIV-infection.
Rodriguez B, Valdez H, Lange CG, Asaad R, Medvik K, Sieg SF. Rodriguez B, et al. Clin Immunol. 2010 Sep;136(3):400-8. doi: 10.1016/j.clim.2010.04.016. Epub 2010 May 15. Clin Immunol. 2010. PMID: 20472504 Free PMC article.
Immunological dysfunction in HIV-1-infected individuals caused by impairment of adenosine deaminase-induced costimulation of T-cell activation.
Martinez-Navio JM, Climent N, Pacheco R, Garcia F, Plana M, Nomdedeu M, Oliva H, Rovira C, Miralles L, Gatell JM, Gallart T, Mallol J, Lluis C, Franco R. Martinez-Navio JM, et al. Immunology. 2009 Nov;128(3):393-404. doi: 10.1111/j.1365-2567.2009.03121.x. Immunology. 2009. PMID: 20067539 Free PMC article.
Proximity to traffic, inflammation, and immune function among women in the Seattle, Washington, area.
Williams LA, Ulrich CM, Larson T, Wener MH, Wood B, Campbell PT, Potter JD, McTiernan A, De Roos AJ. Williams LA, et al. Environ Health Perspect. 2009 Mar;117(3):373-8. doi: 10.1289/ehp.11580. Epub 2008 Oct 16. Environ Health Perspect. 2009. PMID: 19337511 Free PMC article.
HIV-induced changes in T cell signaling pathways.
Schweneker M, Favre D, Martin JN, Deeks SG, McCune JM. Schweneker M, et al. J Immunol. 2008 May 15;180(10):6490-500. doi: 10.4049/jimmunol.180.10.6490. J Immunol. 2008. PMID: 18453567 Free PMC article.

References

1. J Immunol. 1989 Mar 15;142(6):1874-80 - PubMed
1. J Clin Immunol. 1989 Mar;9(2):159-68 - PubMed
1. Science. 1986 Feb 28;231(4741):992-5 - PubMed
1. J Immunol. 1980 Jun;124(6):2708-13 - PubMed
1. Nature. 1988 Jun 9;333(6173):514-9 - PubMed

Low T-cell responsiveness to activation via CD3/TCR is a prognostic marker for acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus-1 (HIV-1)-infected men - PubMed (original) (raw)