Murine models of systemic lupus erythematosus - PubMed (original) (raw)

Review

Murine models of systemic lupus erythematosus

Daniel Perry et al. J Biomed Biotechnol. 2011.

Abstract

Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disorder. The study of diverse mouse models of lupus has provided clues to the etiology of SLE. Spontaneous mouse models of lupus have led to identification of numerous susceptibility loci from which several candidate genes have emerged. Meanwhile, induced models of lupus have provided insight into the role of environmental factors in lupus pathogenesis as well as provided a better understanding of cellular mechanisms involved in the onset and progression of disease. The SLE-like phenotypes present in these models have also served to screen numerous potential SLE therapies. Due to the complex nature of SLE, it is necessary to understand the effect specific targeted therapies have on immune homeostasis. Furthermore, knowledge gained from mouse models will provide novel therapy targets for the treatment of SLE.

PubMed Disclaimer

Figures

Figure 1

Figure 1

Integration of human and murine studies for new SLE drug discovery. Study of human SLE patients and mouse models of lupus has led to the identification of potential therapeutic targets. In-depth studies in murine models are undertaken to validate the association of the potential targets with disease symptoms. The efficacy of targeted treatments are first tested on murine models of lupus prior to the initiation of human clinical trials.

References

    1. Moser KL, Kelly JA, Lessard CJ, Harley JB. Recent insights into the genetic basis of systemic lupus erythematosus. Genes and Immunity. 2009;10(5):373–379. - PMC - PubMed
    1. Kono DH, Theofilopoulos AN. Genetics of SLE in mice. Springer Seminars in Immunopathology. 2006;28(2):83–96. - PubMed
    1. Morel L. Genetics of SLE: evidence from mouse models. Nature Reviews Rheumatology. 2010;6(6):348–357. - PubMed
    1. Theofilopoulos AN, Dixon FJ. Murine models of systemic lupus erythematosus. Advances in Immunology. 1985;37:269–390. - PubMed
    1. Roubinian JR, Talal N, Greenspan JS, Goodman JR, Siiteri PK. Effect of castration and sex hormone treatment on survival, anti-nucleic acid antibodies, and glomerulonephritis in NZB/NZW F mice. Journal of Experimental Medicine. 1978;147(6):1568–1583. - PMC - PubMed

Publication types

MeSH terms

LinkOut - more resources