Human placenta contains an epithelial scatter protein - PubMed (original) (raw)

Human placenta contains an epithelial scatter protein

E M Rosen et al. Biochem Biophys Res Commun. 1990.

Free article

Abstract

Scatter factor (SF) is a protein produced by cultured fibroblasts which causes epithelia to "scatter" into isolated cells. We found significant scatter activity in vivo in second trimester (but not term) human amniotic fluid and in human placenta. Placental SF was purified 500,000-fold and identified as a protein with Mr 78 kd. Factor scattered Madin-Darby canine kidney and human squamous carcinoma cells at 15 pM. Amino acid sequences from tryptic peptides did not match any known protein. Human placental fibroblasts produced high titers of scatter activity. SF may be involved in development and may enhance carcinoma invasion.

PubMed Disclaimer

Similar articles

• Purified scatter factor stimulates epithelial and vascular endothelial cell migration.
  Rosen EM, Meromsky L, Setter E, Vinter DW, Goldberg ID. Rosen EM, et al. Proc Soc Exp Biol Med. 1990 Oct;195(1):34-43. doi: 10.3181/00379727-195-43115. Proc Soc Exp Biol Med. 1990. PMID: 2144630
• Purification of placental protein PP12 from human amniotic fluid and its comparison with PP12 from placenta by immunological, physicochemical and somatomedin-binding properties.
  Koistinen R, Huhtala ML, Stenman UH, Seppälä M. Koistinen R, et al. Clin Chim Acta. 1987 May 15;164(3):293-303. doi: 10.1016/0009-8981(87)90304-4. Clin Chim Acta. 1987. PMID: 3109787
• Scatter factor and hepatocyte growth factor: activities, properties, and mechanism.
  Bhargava M, Joseph A, Knesel J, Halaban R, Li Y, Pang S, Goldberg I, Setter E, Donovan MA, Zarnegar R, et al. Bhargava M, et al. Cell Growth Differ. 1992 Jan;3(1):11-20. Cell Growth Differ. 1992. PMID: 1534687
• [Specific proteins of pregnancy in the diagnosis of feto-placental insufficiency].
  Sokolova ZP, Golubev VA, Nyrkova VI, El'tsova-Strelkova VM. Sokolova ZP, et al. Akush Ginekol (Mosk). 1986 Jan;(1):10-3. Akush Ginekol (Mosk). 1986. PMID: 2421595 Review. Russian. No abstract available.
• Purification, characterization and mechanism of action of scatter factor from human placenta.
  Bhargava MM, Li Y, Joseph A, Pendergast M, Hofmann R, Rosen EM, Goldberg ID. Bhargava MM, et al. EXS. 1991;59:63-75. doi: 10.1007/978-3-0348-7494-6_5. EXS. 1991. PMID: 1833232 Review.

Cited by

• Evidence for the identity of human scatter factor and human hepatocyte growth factor.
  Weidner KM, Arakaki N, Hartmann G, Vandekerckhove J, Weingart S, Rieder H, Fonatsch C, Tsubouchi H, Hishida T, Daikuhara Y, et al. Weidner KM, et al. Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7001-5. doi: 10.1073/pnas.88.16.7001. Proc Natl Acad Sci U S A. 1991. PMID: 1831266 Free PMC article.
• The presence of scatter factor in patients with metastatic spread to the pleura.
  Kenworthy P, Dowrick P, Baillie-Johnson H, McCann B, Tsubouchi H, Arakaki N, Daikuhara Y, Warn RM. Kenworthy P, et al. Br J Cancer. 1992 Aug;66(2):243-7. doi: 10.1038/bjc.1992.251. Br J Cancer. 1992. PMID: 1387000 Free PMC article.
• Purification and characterization of biologically active scatter factor from ras-transformed NIH 3T3 conditioned medium.
  Coffer A, Fellows J, Young S, Pappin D, Rahman D. Coffer A, et al. Biochem J. 1991 Aug 15;278 ( Pt 1)(Pt 1):35-41. doi: 10.1042/bj2780035. Biochem J. 1991. PMID: 1831975 Free PMC article.
• Immunohistochemical detection of hepatocyte growth factor/scatter factor in human cancerous and inflammatory lesions of various organs.
  Yoshinaga Y, Matsuno Y, Fujita S, Nakamura T, Kikuchi M, Shimosato Y, Hirohashi S. Yoshinaga Y, et al. Jpn J Cancer Res. 1993 Nov;84(11):1150-8. doi: 10.1111/j.1349-7006.1993.tb02815.x. Jpn J Cancer Res. 1993. PMID: 8276720 Free PMC article.
• Effect of scatter factor and hepatocyte growth factor on motility and morphology of MDCK cells.
  Li Y, Joseph A, Bhargava MM, Rosen EM, Nakamura T, Goldberg I. Li Y, et al. In Vitro Cell Dev Biol. 1992 May;28A(5):364-8. doi: 10.1007/BF02877060. In Vitro Cell Dev Biol. 1992. PMID: 1534555

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Molecular Biology Databases

  • GlyGen glycoinformatics resource