An examination of the time course of training-induced skeletal muscle hypertrophy - PubMed (original) (raw)

Clinical Trial

. 2011 Nov;111(11):2785-90.

doi: 10.1007/s00421-011-1905-4. Epub 2011 Mar 16.

Affiliations

• PMID: 21409401
• DOI: 10.1007/s00421-011-1905-4

Clinical Trial

An examination of the time course of training-induced skeletal muscle hypertrophy

Jason M DeFreitas et al. Eur J Appl Physiol. 2011 Nov.

Abstract

Skeletal muscle hypertrophy is typically considered to be a slow process. However, this is partly because the time course for hypertrophy has not been thoroughly examined. The purpose of this study was to use weekly testing to determine a precise time course of skeletal muscle hypertrophy during a resistance training program. Twenty-five healthy, sedentary men performed 8 weeks of high-intensity resistance training. Whole muscle cross-sectional area (CSA) of the dominant thigh was assessed using a peripheral quantitative computed tomography scanner during each week of training (W1-W8). Isometric maximum voluntary contractions (MVC) were also measured each week. After only two training sessions (W1), the mean thigh muscle CSA increased by 5.0 cm(2) (3.46%; p < 0.05) from the pre-testing (P1) and continued to increase with each testing session. It is possible that muscular edema may have influenced the early CSA results. To adjust for this possibility, with edema assumedly at its highest at W1, the next significant increase from W1 was at W3. W4 was the first significant increase of MVC over P1. Therefore, significant skeletal muscle hypertrophy likely occurred around weeks 3-4. Overall, from the pre-testing to W8, there was an increase of 13.9 cm(2) (9.60%). These findings suggested that training-induced skeletal muscle hypertrophy may occur early in a training program.

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Comment in

• Eur J Appl Physiol. 2016 Feb;116(2):443-4
• The findings of Damas et al. have not influenced the previously proposed time course of skeletal muscle hypertrophy.
  DeFreitas JM, Beck TW, Stock MS. DeFreitas JM, et al. Eur J Appl Physiol. 2016 Feb;116(2):443-4. doi: 10.1007/s00421-015-3286-6. Eur J Appl Physiol. 2016. PMID: 26497192 No abstract available.
• An inability to distinguish edematous swelling from true hypertrophy still prevents a completely accurate interpretation of the time course of muscle hypertrophy.
  Damas F, Phillips SM, Lixandrão ME, Vechin FC, Libardi CA, Roschel H, Tricoli V, Ugrinowitsch C. Damas F, et al. Eur J Appl Physiol. 2016 Feb;116(2):445-6. doi: 10.1007/s00421-015-3287-5. Epub 2015 Oct 29. Eur J Appl Physiol. 2016. PMID: 26515294 No abstract available.

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