Chemopreventive effect of dietary polyphenols in colorectal cancer cell lines - PubMed (original) (raw)
Review
Chemopreventive effect of dietary polyphenols in colorectal cancer cell lines
João R Araújo et al. Nutr Res. 2011 Feb.
Abstract
Colorectal cancer (CRC) is the second most fatal and the third most diagnosed type of cancer worldwide. Despite having multifactorial causes, most CRC cases are mainly determined by dietary factors. In recent years, a large number of studies have attributed a protective effect to polyphenols and foods containing these compounds (fruits and vegetables) against CRC. Indeed, polyphenols have been reported to interfere with cancer initiation, promotion, and progression, acting as chemopreventive agents. The aim of this review is to summarize the main chemopreventive properties of some polyphenols (quercetin, rutin, myricetin, chrysin, epigallocatechin-3-gallate, epicatechin, catechin, resveratrol, and xanthohumol) against CRC, observed in cell culture models. From the data reviewed in this article, it can be concluded that these compounds inhibit cell growth, by inducing cell cycle arrest and/or apoptosis; inhibit proliferation, angiogenesis, and/or metastasis; and exhibit anti-inflammatory and/or antioxidant effects. In turn, these effects involve multiple molecular and biochemical mechanisms of action, which are still not completely characterized. Thus, caution is mandatory when attempting to extrapolate the observations obtained in CRC cell line studies to humans.
Copyright © 2011 Elsevier Inc. All rights reserved.
Similar articles
- In vitro studies on the inhibition of colon cancer by butyrate and polyphenolic compounds.
Gonçalves P, Araújo JR, Pinho MJ, Martel F. Gonçalves P, et al. Nutr Cancer. 2011;63(2):282-94. doi: 10.1080/01635581.2011.523166. Nutr Cancer. 2011. PMID: 21207318 - Green tea polyphenols and its constituent epigallocatechin gallate inhibits proliferation of human breast cancer cells in vitro and in vivo.
Thangapazham RL, Singh AK, Sharma A, Warren J, Gaddipati JP, Maheshwari RK. Thangapazham RL, et al. Cancer Lett. 2007 Jan 8;245(1-2):232-41. doi: 10.1016/j.canlet.2006.01.027. Epub 2006 Mar 6. Cancer Lett. 2007. PMID: 16519995 - Comparative effects of food-derived polyphenols on the viability and apoptosis of a human hepatoma cell line (HepG2).
Ramos S, Alía M, Bravo L, Goya L. Ramos S, et al. J Agric Food Chem. 2005 Feb 23;53(4):1271-80. doi: 10.1021/jf0490798. J Agric Food Chem. 2005. PMID: 15713052 - New insights on the anticancer properties of dietary polyphenols.
Fresco P, Borges F, Diniz C, Marques MP. Fresco P, et al. Med Res Rev. 2006 Nov;26(6):747-66. doi: 10.1002/med.20060. Med Res Rev. 2006. PMID: 16710860 Review. - Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention.
Ramos S. Ramos S. J Nutr Biochem. 2007 Jul;18(7):427-42. doi: 10.1016/j.jnutbio.2006.11.004. Epub 2007 Feb 23. J Nutr Biochem. 2007. PMID: 17321735 Review.
Cited by
- New Insights Into the Anticancer Effects of _p_-Coumaric Acid: Focus on Colorectal Cancer.
Tehami W, Nani A, Khan NA, Hichami A. Tehami W, et al. Dose Response. 2023 Jan 4;21(1):15593258221150704. doi: 10.1177/15593258221150704. eCollection 2023 Jan-Mar. Dose Response. 2023. PMID: 36636631 Free PMC article. Review. - Activities of the soluble and non-digestible longan (Dimocarpus longan Lour.) polysaccharides against HCT-116 cells as affected by a chemical selenylation.
Yu YH, Wang L, Zhang Q, Zhang XN, Zhao XH. Yu YH, et al. Curr Res Food Sci. 2022 Jun 24;5:1071-1083. doi: 10.1016/j.crfs.2022.06.008. eCollection 2022. Curr Res Food Sci. 2022. PMID: 35799859 Free PMC article. - Quercetin Inhibits Fibroblast Activation and Kidney Fibrosis Involving the Suppression of Mammalian Target of Rapamycin and β-catenin Signaling.
Ren J, Li J, Liu X, Feng Y, Gui Y, Yang J, He W, Dai C. Ren J, et al. Sci Rep. 2016 Apr 7;6:23968. doi: 10.1038/srep23968. Sci Rep. 2016. PMID: 27052477 Free PMC article. - Evidence for Anticancer Effects of Chinese Medicine Monomers on Colorectal Cancer.
Guo TH, Li YY, Hong SW, Cao QY, Chen H, Xu Y, Dai GL, Shao G. Guo TH, et al. Chin J Integr Med. 2022 Oct;28(10):939-952. doi: 10.1007/s11655-022-3466-2. Epub 2022 Apr 13. Chin J Integr Med. 2022. PMID: 35419728 Review. - Development and validation of a reverse phase HPLC-DAD method for separation, detection & quantification of rutin and quercetin in buckwheat (Fagopyrum spp_._).
Jan S, Ahmad J, Dar MM, Wani AA, Tahir I, Kamili AN. Jan S, et al. J Food Sci Technol. 2022 Jul;59(7):2875-2883. doi: 10.1007/s13197-021-05312-0. Epub 2021 Nov 29. J Food Sci Technol. 2022. PMID: 35734108 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical