Correlation between the V beta 4+ CD8+ T-cell population and the H-2d haplotype - PubMed (original) (raw)

Correlation between the V beta 4+ CD8+ T-cell population and the H-2d haplotype

K Tomonari et al. Immunogenetics. 1990.

Abstract

The V beta 4+ T-cell population was examined with a newly established antibody, KT4, specific for V beta 4. Between 4.8% and 19.4% of CD3+ peripheral T cells from various inbred strains of mice or F1 hybrids expressed V beta 4. The CD4 T-cell population had higher numbers of V beta 4+ T cells (5.5%-20.6%) than the CD8 T-cell population (2.5%-10.7%). Deletion of certain V beta-expressing T cells due to the presence of the Mlsa antigen and/or the absence of certain Tcrb-V genes increased relative numbers of V beta 4+ T cells. The data suggest that V beta 4+ CD8+ T cells might be positively selected by H-2d molecules.

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