The effect of Helicobacter pylori on asthma and allergy - PubMed (original) (raw)

The effect of Helicobacter pylori on asthma and allergy

Amedeo Amedei et al. J Asthma Allergy. 2010.

Abstract

Current evidence indicates an inverse association between Helicobacter pylori and asthma and allergy. H. pylori is a Gram-negative bacterium which represents the major cause of peptic ulcer and gastric cancer, and preferentially elicits a T helper (Th)-1 response. Many H. pylori factors, such as the neutrophil-activating factor of H. pylori (HP-NAP), are able to drive Th-1 polarization and to display a powerful inhibition of allergic Th-2 response. This article proposes an overview of the actual knowledge about the effects of H. pylori on asthma and allergy. Special attention has been drawn to HP-NAP as a potential novel strategy for the prevention and treatment of asthma and atopy.

Keywords: Helicobacter pylori neutrophil-activating factor; Th-1/Th-2; Treg; asthma; protein.

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Figures

Figure 1

Figure 1

Schematic representation of _Helicobacter pylori-_driven inhibition of allergic Th-2 inflammation via activation of Th-1 responses. Following H. pylori infection, HP-NAP and other H. pylori factors induce the production of IL-12 and IL-23 that both promote the preferential development of Th-1 cells and repress the Th-2 allergic response. Abbreviations: HP-NAP, H. pylori neutrophil-activating protein; Th, T helper; IL, interleukin; IFN, interferon; TFN, tumor necrosis factor.

Figure 2

Figure 2

Inhibition of Th-2 response might hypothetically occur by _Helicobacter pylori_-induced activation of regulatory T cells. Abbreviations: Th, T helper; Treg, regulatory T cell.

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