Highly conserved influenza A sequences as T cell epitopes-based vaccine targets to address the viral variability - PubMed (original) (raw)
Review
doi: 10.4161/hv.7.4.13845. Epub 2011 Apr 1.
Affiliations
- PMID: 21471731
- DOI: 10.4161/hv.7.4.13845
Review
Highly conserved influenza A sequences as T cell epitopes-based vaccine targets to address the viral variability
Paul Thiamjoo Tan et al. Hum Vaccin. 2011 Apr.
Abstract
Vaccines are the only proven effective method for prevention of human infectious diseases. Almost all traditional vaccines require activating immunological memory B cells to secrete neutralizing antibodies against invading pathogens. The complication with influenza viruses is the high viral mutation rate that results in immune escape through modification of the B cell epitopes. Studies of T-cell immunity to influenza infection provide an alternative vaccine strategy based on highly conserved T-cell epitopes. In this review, we discuss the importance of T cell-mediated immunity in influenza infection and the need for a targeted vaccine approach focused on highly conserved T-cell epitopes to mitigate immune escape. We propose 15 highly conserved pan-influenza sequences as possible T cell epitopes-based vaccine targets for broad protection and lasting immunity against variant influenza strains.
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