Blocking HIF1α activity eliminates hematological cancer stem cells - PubMed (original) (raw)
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Blocking HIF1α activity eliminates hematological cancer stem cells
Ben S Lam et al. Cell Stem Cell. 2011.
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Abstract
Selective targeting of cancer stem cells (CSCs) has the potential to prevent cancer relapse. Wang et al. (2011) report that hypoxia-inducible factor 1α (HIF1α) represses Notch signaling to maintain CSC subsets from lymphoma, and that blocking HIF1α activity eliminates lymphoma and human acute myeloid leukemia (AML) CSCs.
Copyright © 2011 Elsevier Inc. All rights reserved.
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- Targeting HIF1α eliminates cancer stem cells in hematological malignancies.
Wang Y, Liu Y, Malek SN, Zheng P, Liu Y. Wang Y, et al. Cell Stem Cell. 2011 Apr 8;8(4):399-411. doi: 10.1016/j.stem.2011.02.006. Cell Stem Cell. 2011. PMID: 21474104 Free PMC article.
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