Cell type-specific and activity-dependent dynamics of action potential-evoked Ca2+ signals in dendrites of hippocampal inhibitory interneurons - PubMed (original) (raw)

A and B, summary plots and representative AP-CaTs recorded using Fluo-5F in a control setting (black trace) and 10–15 min after the administration of blockers (green trace) of L-type (nifedipine, 10 μ

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; Aa, Ba, left), R-type (SNX-482, 10 μ

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; Aa, Ba, right), T-type (NNC 55-0396, 10 μ

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; Ab, Bb, left), P/Q-type (ω-agatoxin IVA (AgTx), 250 n

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; Ac, Bc, left) and N-type (ω-conotoxin GVIA (CTx), 250 n

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; Ac, Bc, right) VSCCs and intracellular Ca2+ stores (CPA, 30 μ

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; Ab, Bb, right) in SC-ACs (A) and BCs (B). C, summary bar graph of group data for AP-CaT mechanisms, showing that L- and T-type VSCCs and stores contributed to AP-CaTs in SC-ACs, whereas L-, T- and P/Q-type VSCCs and stores mediated AP-CaTs in BCs. Data are expressed as percentages of control CaTs obtained prior to drug application. D, Neurolucida reconstructions of the two representative biocytin-filled INs from which the recordings were obtained, with axonal arborization shown in red and dendrites shown in black.