Notch signalling in solid tumours: a little bit of everything but not all the time - PubMed (original) (raw)
Review
doi: 10.1038/nrc3035. Epub 2011 Apr 14.
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- PMID: 21508972
- DOI: 10.1038/nrc3035
Review
Notch signalling in solid tumours: a little bit of everything but not all the time
Prathibha Ranganathan et al. Nat Rev Cancer. 2011 May.
Abstract
The discovery of Notch in Drosophila melanogaster nearly a century ago opened the door to an ever-widening understanding of cellular processes that are controlled or influenced by Notch signalling. As would be expected with such a pleiotropic pathway, the deregulation of Notch signalling leads to several pathological conditions, including cancer. A role for Notch is well established in haematological malignancies, and more recent studies have provided evidence for the importance of Notch activity in solid tumours. As it is thought to act as an oncogene in some cancers but as a tumour suppressor in others, the role of Notch in solid tumours seems to be highly context dependent.
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References
- Mol Cell Biol. 2001 Nov;21(21):7403-15 - PubMed
- Nature. 2006 Dec 7;444(7120):756-60 - PubMed
- J Neurosci Res. 2009 Dec;87(16):3521-34 - PubMed
- J Exp Med. 2007 Nov 26;204(12):2935-48 - PubMed
- Nat Genet. 2000 Mar;24(3):245-50 - PubMed
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