Random-effects model aimed at discovering associations in meta-analysis of genome-wide association studies - PubMed (original) (raw)

Novel functional insights into ischemic stroke biology provided by the first genome-wide association study of stroke in indigenous Africans.

Akinyemi RO, Tiwari HK, Srinivasasainagendra V, Akpa O, Sarfo FS, Akpalu A, Wahab K, Obiako R, Komolafe M, Owolabi L, Osaigbovo GO, Mamaeva OA, Halloran BA, Akinyemi J, Lackland D, Obiabo OY, Sunmonu T, Chukwuonye II, Arulogun O, Jenkins C, Adeoye A, Agunloye A, Ogah OS, Ogbole G, Fakunle A, Uvere E, Coker MM, Okekunle A, Asowata O, Diala S, Ogunronbi M, Adeleye O, Laryea R, Tagge R, Adeniyi S, Adusei N, Oguike W, Olowoyo P, Adebajo O, Olalere A, Oladele O, Yaria J, Fawale B, Ibinaye P, Oyinloye O, Mensah Y, Oladimeji O, Akpalu J, Calys-Tagoe B, Dambatta HA, Ogunniyi A, Kalaria R, Arnett D, Rotimi C, Ovbiagele B, Owolabi MO; SIREN Team. Akinyemi RO, et al. Genome Med. 2024 Feb 5;16(1):25. doi: 10.1186/s13073-023-01273-5. Genome Med. 2024. PMID: 38317187 Free PMC article.

A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences.

Hoffmann TJ, Van Den Eeden SK, Sakoda LC, Jorgenson E, Habel LA, Graff RE, Passarelli MN, Cario CL, Emami NC, Chao CR, Ghai NR, Shan J, Ranatunga DK, Quesenberry CP, Aaronson D, Presti J, Wang Z, Berndt SI, Chanock SJ, McDonnell SK, French AJ, Schaid DJ, Thibodeau SN, Li Q, Freedman ML, Penney KL, Mucci LA, Haiman CA, Henderson BE, Seminara D, Kvale MN, Kwok PY, Schaefer C, Risch N, Witte JS. Hoffmann TJ, et al. Cancer Discov. 2015 Aug;5(8):878-91. doi: 10.1158/2159-8290.CD-15-0315. Epub 2015 Jun 1. Cancer Discov. 2015. PMID: 26034056 Free PMC article.

Identification of new risk loci shared across systemic vasculitides points towards potential target genes for drug repurposing.

Ortiz-Fernández L, Carmona EG, Kerick M, Lyons P, Carmona FD, López Mejías R, Khor CC, Grayson PC, Tombetti E, Jiang L, Direskeneli H, Saruhan-Direskeneli G, Callejas-Rubio JL, Vaglio A, Salvarani C, Hernández-Rodríguez J, Cid MC, Morgan AW, Merkel PA, Burgner D, Smith KG, Gonzalez-Gay MA, Sawalha AH, Martin J, Marquez A. Ortiz-Fernández L, et al. Ann Rheum Dis. 2023 Jun;82(6):837-847. doi: 10.1136/ard-2022-223697. Epub 2023 Feb 16. Ann Rheum Dis. 2023. PMID: 36797040 Free PMC article.