Interleukin 3 as a trophic factor for central cholinergic neurons in vitro and in vivo - PubMed (original) (raw)
Interleukin 3 as a trophic factor for central cholinergic neurons in vitro and in vivo
M Kamegai et al. Neuron. 1990 Mar.
Abstract
We have found that interleukin 3 (IL-3), a growth factor for hematopoietic cells, is a novel trophic factor for mouse and rat central cholinergic neurons. It enhanced neurite outgrowth and elevated choline acetyltransferase activity. The effect seems to be specific for cholinergic neurons, since somatostatin release and glutamic acid decarboxylase and 2',3'-cyclic nucleotide 3'-phosphodiesterase activities were not significantly influenced by IL-3. In vivo, IL-3 was infused into the lateral ventricles of rats after unilateral axotomy of the septohippocampal pathways. Two weeks later, the IL-3-treated animals showed significant numbers of acetylcholinesterase-positive neurons remaining in the septal region.
Similar articles
- Nerve growth factor increases choline acetyltransferase but not survival or fiber outgrowth of cultured fetal septal cholinergic neurons.
Hefti F, Hartikka J, Eckenstein F, Gnahn H, Heumann R, Schwab M. Hefti F, et al. Neuroscience. 1985 Jan;14(1):55-68. doi: 10.1016/0306-4522(85)90163-0. Neuroscience. 1985. PMID: 3974885 - Epidermal growth factor affects both glia and cholinergic neurons in septal cell cultures.
Kenigsberg RL, Mazzoni IE, Collier B, Cuello AC. Kenigsberg RL, et al. Neuroscience. 1992 Sep;50(1):85-97. doi: 10.1016/0306-4522(92)90383-d. Neuroscience. 1992. PMID: 1407562 - Microglia from the developing rat medial septal area can affect cholinergic and GABAergic neuronal differentiation in vitro.
Mazzoni IE, Kenigsberg RL. Mazzoni IE, et al. Neuroscience. 1997 Jan;76(1):147-57. doi: 10.1016/s0306-4522(96)00235-7. Neuroscience. 1997. PMID: 8971767 - Septal neuron cholinergic and GABAergic functions: differential regulation by basic fibroblast growth factor and epidermal growth factor.
Yokoyama M, Morrison RS, Black IB, Dreyfus CF. Yokoyama M, et al. Brain Res Dev Brain Res. 1994 Apr 15;78(2):201-9. doi: 10.1016/0165-3806(94)90027-2. Brain Res Dev Brain Res. 1994. PMID: 8026075
Cited by
- The interleukin 3 gene (IL3) contributes to human brain volume variation by regulating proliferation and survival of neural progenitors.
Luo XJ, Li M, Huang L, Nho K, Deng M, Chen Q, Weinberger DR, Vasquez AA, Rijpkema M, Mattay VS, Saykin AJ, Shen L, Fernández G, Franke B, Chen JC, Chen XN, Wang JK, Xiao X, Qi XB, Xiang K, Peng YM, Cao XY, Li Y, Shi XD; Alzheimer’s Disease Neuroimaging Initiative; Gan L, Su B. Luo XJ, et al. PLoS One. 2012;7(11):e50375. doi: 10.1371/journal.pone.0050375. Epub 2012 Nov 30. PLoS One. 2012. PMID: 23226269 Free PMC article. - Differential immune responses to fetal intracameral spinal cord and cortex cerebri grafts.
Shinoda M, Giacobini M, Schmidt-Kastner R, Trok K, Olson L. Shinoda M, et al. Exp Brain Res. 1996 Jul;110(2):223-34. doi: 10.1007/BF00228554. Exp Brain Res. 1996. PMID: 8836687 - Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy.
Mandler M, Valera E, Rockenstein E, Mante M, Weninger H, Patrick C, Adame A, Schmidhuber S, Santic R, Schneeberger A, Schmidt W, Mattner F, Masliah E. Mandler M, et al. Mol Neurodegener. 2015 Mar 19;10:10. doi: 10.1186/s13024-015-0008-9. Mol Neurodegener. 2015. PMID: 25886309 Free PMC article. - The cholinergic neuronal phenotype in Alzheimer's disease.
Blusztajn JK, Berse B. Blusztajn JK, et al. Metab Brain Dis. 2000 Mar;15(1):45-64. doi: 10.1007/BF02680013. Metab Brain Dis. 2000. PMID: 10885540 Review. - Regulatory region in choline acetyltransferase gene directs developmental and tissue-specific expression in transgenic mice.
Lönnerberg P, Lendahl U, Funakoshi H, Arhlund-Richter L, Persson H, Ibáñez CF. Lönnerberg P, et al. Proc Natl Acad Sci U S A. 1995 Apr 25;92(9):4046-50. doi: 10.1073/pnas.92.9.4046. Proc Natl Acad Sci U S A. 1995. PMID: 7732028 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources