Reverse cholesterol transport revisited: contribution of biliary versus intestinal cholesterol excretion - PubMed (original) (raw)
Review
. 2011 Aug;31(8):1726-33.
doi: 10.1161/ATVBAHA.108.181206. Epub 2011 May 12.
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- PMID: 21571685
- DOI: 10.1161/ATVBAHA.108.181206
Review
Reverse cholesterol transport revisited: contribution of biliary versus intestinal cholesterol excretion
Gemma Brufau et al. Arterioscler Thromb Vasc Biol. 2011 Aug.
Abstract
Reverse cholesterol transport (RCT) is usually defined as high-density lipoprotein-mediated transport of excess cholesterol from peripheral tissues, including cholesterol-laden macrophages in vessel walls, to the liver. From the liver, cholesterol can then be removed from the body via secretion into the bile for eventual disposal via the feces. According to this paradigm, high plasma high-density lipoprotein levels accelerate RCT and hence are atheroprotective. New insights in individual steps of the RCT pathway, in part derived from innovative mouse models, indicate that the classical concept of RCT may require modification.
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