Antibiotics in the clinical pipeline in 2011 - PubMed (original) (raw)

Review

doi: 10.1038/ja.2011.44. Epub 2011 May 18.

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• PMID: 21587262
• DOI: 10.1038/ja.2011.44

Review

Antibiotics in the clinical pipeline in 2011

Mark S Butler et al. J Antibiot (Tokyo). 2011 Jun.

Abstract

The emergence of multi-drug-resistant bacteria and the lack of new antibiotics in the antibiotic drug development pipeline, especially those with new modes of action, is a major health concern. This review lists the 20 new antibiotics launched since 2000 and records the 40 compounds currently in active clinical development. Compounds in the pipeline from new antibiotic classes are reviewed in detail with reference to their development status, mode of action, spectrum of activity and lead discovery. In addition, the NP or synthetic derivation is discussed, with activity against Gram-negative bacteria highlighted.

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Comment in

• Winners of the 2013 JA Medals for excellence.
  Wright GD, Yoshida M. Wright GD, et al. J Antibiot (Tokyo). 2014 May;67(5):351-2. doi: 10.1038/ja.2014.29. J Antibiot (Tokyo). 2014. PMID: 24862629 No abstract available.

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