Vascular endothelial growth factor expression correlates with hematogenous metastasis and prognosis in colorectal carcinoma - PubMed (original) (raw)
. 1997 Mar-Apr;4(2):381-4.
K Maeda, Y Chung, N Onoda, Y Ogawa, S Takatsuka, M Ogawa, T Sawada, B Nakata, Y Nishiguchi, T Ikehara, M Okuno, M Sowa
- PMID: 21590063
Vascular endothelial growth factor expression correlates with hematogenous metastasis and prognosis in colorectal carcinoma
S Kang et al. Oncol Rep. 1997 Mar-Apr.
Abstract
We investigated the expression of vascular endothelial growth factor (VEGF) in 175 colorectal carcinomas by immunohistochemistry. VEGF expression was correlated with advanced TNM stage (III, IV), advanced T stage (T3, T4), vessel involvement, lymph node metastasis, and liver metastasis. With regard to the prognosis, both overall and relapse-free survival was significantly poorer, and furthermore, the hematogenous recurrences were significantly more commonly found in the patients with VEGF-positive tumors. VEGF expresion in colorectal carcinomas may have a substantial value in predicting those patients at high risk for hematogenous recurrence after surgery.
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