Nuclear receptor that identifies a novel retinoic acid response pathway - PubMed (original) (raw)

Comparative Study

. 1990 May 17;345(6272):224-9.

doi: 10.1038/345224a0.

Affiliations

• PMID: 2159111
• DOI: 10.1038/345224a0

Comparative Study

Nuclear receptor that identifies a novel retinoic acid response pathway

D J Mangelsdorf et al. Nature. 1990.

Abstract

Molecular cloning and transcriptional activation studies have revealed a new protein similar to the steroid hormone receptors and which responds specifically to vitamin A metabolites. This protein is substantially different in primary structure and ligand specificity from the products of the previously described retinoic acid receptor gene family. By indicating the existence of an additional pathway through which retinoic acid may exert its effects, these data lead to a re-evaluation of retinoid physiology.

PubMed Disclaimer

Similar articles

• A human retinoic acid receptor which belongs to the family of nuclear receptors.
  Petkovich M, Brand NJ, Krust A, Chambon P. Petkovich M, et al. Nature. 1987 Dec 3-9;330(6147):444-50. doi: 10.1038/330444a0. Nature. 1987. PMID: 2825025 Review.
• Relationship between the product of the Drosophila ultraspiracle locus and the vertebrate retinoid X receptor.
  Oro AE, McKeown M, Evans RM. Oro AE, et al. Nature. 1990 Sep 20;347(6290):298-301. doi: 10.1038/347298a0. Nature. 1990. PMID: 2169594
• Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene.
  de Thé H, Vivanco-Ruiz MM, Tiollais P, Stunnenberg H, Dejean A. de Thé H, et al. Nature. 1990 Jan 11;343(6254):177-80. doi: 10.1038/343177a0. Nature. 1990. PMID: 2153268
• The nuclear receptors of retinoic acid.
  Darmon M. Darmon M. J Lipid Mediat. 1990 Sep-Oct;2(5):247-56. J Lipid Mediat. 1990. PMID: 1966806 Review. No abstract available.
• The Drosophila gene knirps-related is a member of the steroid-receptor gene superfamily.
  Oro AE, Ong ES, Margolis JS, Posakony JW, McKeown M, Evans RM. Oro AE, et al. Nature. 1988 Dec 1;336(6198):493-6. doi: 10.1038/336493a0. Nature. 1988. PMID: 2848202

Cited by

• Retinoic acid affects the expression of nuclear retinoic acid receptors in tissues of retinol-deficient rats.
  Haq R, Pfahl M, Chytil F. Haq R, et al. Proc Natl Acad Sci U S A. 1991 Sep 15;88(18):8272-6. doi: 10.1073/pnas.88.18.8272. Proc Natl Acad Sci U S A. 1991. PMID: 1654565 Free PMC article.
• Differences in the action and metabolism between retinol and retinoic acid in B lymphocytes.
  Buck J, Myc A, Garbe A, Cathomas G. Buck J, et al. J Cell Biol. 1991 Nov;115(3):851-9. doi: 10.1083/jcb.115.3.851. J Cell Biol. 1991. PMID: 1655814 Free PMC article.
• Transcriptional regulation of the c-jun gene by retinoic acid and E1A during differentiation of F9 cells.
  Kitabayashi I, Kawakami Z, Chiu R, Ozawa K, Matsuoka T, Toyoshima S, Umesono K, Evans RM, Gachelin G, Yokoyama K. Kitabayashi I, et al. EMBO J. 1992 Jan;11(1):167-75. doi: 10.1002/j.1460-2075.1992.tb05039.x. EMBO J. 1992. PMID: 1310930 Free PMC article.
• Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor.
  Göttlicher M, Widmark E, Li Q, Gustafsson JA. Göttlicher M, et al. Proc Natl Acad Sci U S A. 1992 May 15;89(10):4653-7. doi: 10.1073/pnas.89.10.4653. Proc Natl Acad Sci U S A. 1992. PMID: 1316614 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • BioCyc
  • FlyBase
  • GlyGen glycoinformatics resource
  • Guide to Pharmacology