Progress and challenges in translating the biology of atherosclerosis - PubMed (original) (raw)
Review
. 2011 May 19;473(7347):317-25.
doi: 10.1038/nature10146.
Affiliations
- PMID: 21593864
- DOI: 10.1038/nature10146
Review
Progress and challenges in translating the biology of atherosclerosis
Peter Libby et al. Nature. 2011.
Abstract
Atherosclerosis is a chronic disease of the arterial wall, and a leading cause of death and loss of productive life years worldwide. Research into the disease has led to many compelling hypotheses about the pathophysiology of atherosclerotic lesion formation and of complications such as myocardial infarction and stroke. Yet, despite these advances, we still lack definitive evidence to show that processes such as lipoprotein oxidation, inflammation and immunity have a crucial involvement in human atherosclerosis. Experimental atherosclerosis in animals furnishes an important research tool, but extrapolation to humans requires care. Understanding how to combine experimental and clinical science will provide further insight into atherosclerosis and could lead to new clinical applications.
Similar articles
- Beyond LDL-cholesterol: HDL-cholesterol as a target for atherosclerosis prevention.
Parhofer KG. Parhofer KG. Exp Clin Endocrinol Diabetes. 2005 Sep;113(8):414-7. doi: 10.1055/s-2005-865940. Exp Clin Endocrinol Diabetes. 2005. PMID: 16151973 Review. - microRNAs in lipoprotein metabolism and cardiometabolic disorders.
Rotllan N, Price N, Pati P, Goedeke L, Fernández-Hernando C. Rotllan N, et al. Atherosclerosis. 2016 Mar;246:352-60. doi: 10.1016/j.atherosclerosis.2016.01.025. Epub 2016 Jan 18. Atherosclerosis. 2016. PMID: 26828754 Free PMC article. Review. - Variability in blood lipids affects the neutrophil to lymphocyte ratio in patients undergoing elective percutaneous coronary intervention: a retrospective study.
Zhao L, Xu T, Li Y, Luan Y, Lv Q, Fu G, Zhang W. Zhao L, et al. Lipids Health Dis. 2020 Jun 3;19(1):124. doi: 10.1186/s12944-020-01304-9. Lipids Health Dis. 2020. PMID: 32493321 Free PMC article. - Low high-density lipoprotein cholesterol: current status and future strategies for management.
Singh V, Sharma R, Kumar A, Deedwania P. Singh V, et al. Vasc Health Risk Manag. 2010 Oct 29;6:979-96. doi: 10.2147/VHRM.S5685. Vasc Health Risk Manag. 2010. PMID: 21127701 Free PMC article. Review. - Triglyceride-Rich Lipoproteins and Atherosclerotic Cardiovascular Disease: New Insights From Epidemiology, Genetics, and Biology.
Nordestgaard BG. Nordestgaard BG. Circ Res. 2016 Feb 19;118(4):547-63. doi: 10.1161/CIRCRESAHA.115.306249. Circ Res. 2016. PMID: 26892957 Review.
Cited by
- Targeting Inflammatory Pathways in Atherosclerosis: Exploring New Opportunities for Treatment.
d'Aiello A, Filomia S, Brecciaroli M, Sanna T, Pedicino D, Liuzzo G. d'Aiello A, et al. Curr Atheroscler Rep. 2024 Oct 15. doi: 10.1007/s11883-024-01241-3. Online ahead of print. Curr Atheroscler Rep. 2024. PMID: 39404934 Review. - Proteomics Reveals Divergent Cardiac Inflammatory and Metabolic Responses After Inhalation of Ambient Particulate Matter With or Without Ozone.
Ge Y, Nash MS, Winnik WM, Bruno M, Padgett WT, Grindstaff RD, Hazari MS, Farraj AK. Ge Y, et al. Cardiovasc Toxicol. 2024 Oct 14. doi: 10.1007/s12012-024-09931-9. Online ahead of print. Cardiovasc Toxicol. 2024. PMID: 39397197 - Effect of inflammatory factors on myocardial infarction.
Zeng Q, Xu T, Luo Z, Zhou H, Duan Z, Xiong X, Huang M, Li W. Zeng Q, et al. BMC Cardiovasc Disord. 2024 Oct 7;24(1):538. doi: 10.1186/s12872-024-04122-4. BMC Cardiovasc Disord. 2024. PMID: 39375629 Free PMC article. - Unveiling the Mechanism of Protective Effects of Tanshinone as a New Fighter Against Cardiovascular Diseases: A Systematic Review.
Dabbaghi MM, Soleimani Roudi H, Safaei R, Baradaran Rahimi V, Fadaei MR, Askari VR. Dabbaghi MM, et al. Cardiovasc Toxicol. 2024 Sep 22. doi: 10.1007/s12012-024-09921-x. Online ahead of print. Cardiovasc Toxicol. 2024. PMID: 39306819 Review. - Aggregation-induced emission luminescence for angiography and atherosclerotic diagnosis.
Ding Y, Ou G, Wang D. Ding Y, et al. iScience. 2024 Aug 13;27(9):110719. doi: 10.1016/j.isci.2024.110719. eCollection 2024 Sep 20. iScience. 2024. PMID: 39297169 Free PMC article. Review.
References
- Circ Res. 2008 Dec 5;103(12):1402-9 - PubMed
- J Clin Invest. 2002 Mar;109(6):745-53 - PubMed
- J Exp Med. 2009 Sep 28;206(10):2067-77 - PubMed
- Curr Opin Lipidol. 2010 Oct;21(5):404-8 - PubMed
- Ann N Y Acad Sci. 2000 May;902:230-9; discussion 239-40 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical