Molecular mechanisms of cholangiocarcinoma - PubMed (original) (raw)

Molecular mechanisms of cholangiocarcinoma

Giammarco Fava. World J Gastrointest Pathophysiol. 2010.

Abstract

Cholangiocarcinoma (CC), the malignant tumor of the epithelial cells lining the biliary ducts, has undergone a worldwide increase in incidence and mortality. The malignant transformation of the biliary cells originates from a multistep process evolving through chronic inflammation of the biliary tract to CC. In the last few years several advances have been towards understanding and clarifying the molecular mechanisms implicated in the cholangiocarcinogenesis process. However, many pathophysiologic aspects governing the growth of CC are still undefined. The poor prognosis of this tumor underlines the urgent need to codify the underlying molecular mechanisms involved in the growth and progression of CC in order to design effective preventive measures and valid treatment regimens. This review reports on progresses made in the last few years in clarifying the molecular pathways involved in the process of cholangiocarcinogenesis.

Keywords: Apoptosis.; Cholangiocarcinogenesis; Cholangiocarcinoma; Genetic; Invasion; Molecular mechanism.

PubMed Disclaimer

Figures

Figure 1

Figure 1

Cholangiocarcinogenesis model. Proposed mechanisms and cellular events linked to malignant transformation of biliary epithelia.

References

    1. Lazaridis KN, Gores GJ. Cholangiocarcinoma. Gastroenterology. 2005;128:1655–1667. - PubMed
    1. Khan SA, Thomas HC, Davidson BR, Taylor-Robinson SD. Cholangiocarcinoma. Lancet. 2005;366:1303–1314. - PubMed
    1. Patel T. Worldwide trends in mortality from biliary tract malignancies. BMC Cancer. 2002;2:10. - PMC - PubMed
    1. Sirica AE. Cholangiocarcinoma: molecular targeting strategies for chemoprevention and therapy. Hepatology. 2005;41:5–15. - PubMed
    1. Berthiaume EP, Wands J. The molecular pathogenesis of cholangiocarcinoma. Semin Liver Dis. 2004;24:127–137. - PubMed

LinkOut - more resources