Induction of AIDS in rhesus monkeys by molecularly cloned simian immunodeficiency virus - PubMed (original) (raw)

. 1990 Jun 1;248(4959):1109-12.

doi: 10.1126/science.2160735.

Affiliations

• PMID: 2160735
• DOI: 10.1126/science.2160735

Induction of AIDS in rhesus monkeys by molecularly cloned simian immunodeficiency virus

H Kestler et al. Science. 1990.

Abstract

Better understanding of the pathogenesis of acquired immunodeficiency syndrome (AIDS) would be greatly facilitated by a relevant animal model that uses molecularly cloned virus of defined sequence to induce the disease. Such a system would also be of great value for AIDS vaccine research. An infectious molecular clone of simian immunodeficiency virus (SIV) was identified that induces AIDS in common rhesus monkeys in a time frame suitable for laboratory investigation. These results provide another strong link in the chain of evidence for the viral etiology of AIDS. More importantly, they define a system for molecular dissection of the determinants of AIDS pathogenesis.

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Comment in

• A reliable animal model for AIDS.
  Palca J. Palca J. Science. 1990 Jun 1;248(4959):1078. doi: 10.1126/science.2160733. Science. 1990. PMID: 2160733 No abstract available.

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