TGF-β/TGF-β receptor system and its role in physiological and pathological conditions - PubMed (original) (raw)

Review

. 2011 Sep;121(6):233-51.

doi: 10.1042/CS20110086.

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Free article

Review

TGF-β/TGF-β receptor system and its role in physiological and pathological conditions

Juan F Santibañez et al. Clin Sci (Lond). 2011 Sep.

Free article

Abstract

The TGF-β (transforming growth factor-β) system signals via protein kinase receptors and Smad mediators to regulate a plethora of biological processes, including morphogenesis, embryonic development, adult stem cell differentiation, immune regulation, wound healing and inflammation. In addition, alterations of specific components of the TGF-β signalling pathway may contribute to a broad range of pathologies such as cancer, cardiovascular pathology, fibrosis and congenital diseases. The knowledge about the mechanisms involved in TGF-β signal transduction has allowed a better understanding of the disease pathogenicity as well as the identification of several molecular targets with great potential in therapeutic interventions.

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