The golden anniversary of the thymus - PubMed (original) (raw)

Review

. 2011 May 27;11(7):489-95.

doi: 10.1038/nri2993.

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• PMID: 21617694
• DOI: 10.1038/nri2993

Review

The golden anniversary of the thymus

Jacques F A P Miller. Nat Rev Immunol. 2011.

Erratum in

• Nat Rev Immunol. 2011 Dec;11(12):880

Abstract

The immunological function of the thymus was first documented 50 years ago by using neonatally thymectomized mice, while studying its role in virus-induced leukaemia. Since then, an enormous wealth of reports has helped to define the importance of this primary lymphoid organ. In this article, I summarize the key advances that have led to our current knowledge of the functions of the thymus and its T cells in immunity.

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References

1. 1. Proc Natl Acad Sci U S A. 1968 Jan;59(1):296-303 - PubMed
2. 1. Immunity. 1999 May;10(5):547-58 - PubMed
3. 1. Nature. 1990 Apr 19;344(6268):742-6 - PubMed
4. 1. Nature. 2002 Feb 21;415(6874):922-6 - PubMed
5. 1. Contemp Top Immunobiol. 1974;3:1-40 - PubMed

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