Primate CpG islands are maintained by heterogeneous evolutionary regimes involving minimal selection - PubMed (original) (raw)
. 2011 May 27;145(5):773-86.
doi: 10.1016/j.cell.2011.04.024.
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- PMID: 21620139
- DOI: 10.1016/j.cell.2011.04.024
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Primate CpG islands are maintained by heterogeneous evolutionary regimes involving minimal selection
Netta Mendelson Cohen et al. Cell. 2011.
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Abstract
Mammalian CpG islands are key epigenomic elements that were first characterized experimentally as genomic fractions with low levels of DNA methylation. Currently, CpG islands are defined based on their genomic sequences alone. Here, we develop evolutionary models to show that several distinct evolutionary processes generate and maintain CpG islands. One central evolutionary regime resulting in enriched CpG content is driven by low levels of DNA methylation and consequentially low rates of CpG deamination. Another major force forming CpG islands is biased gene conversion that stabilizes constitutively methylated CpG islands by balancing rapid deamination with CpG fixation. Importantly, evolutionary analysis and population genetics data suggest that selection for high CpG content is not a significant factor contributing to conservation of CpGs in differentially methylated regions. The heterogeneous, but not selective, origins of CpG islands have direct implications for the understanding of DNA methylation patterns in healthy and diseased cells.
Copyright © 2011 Elsevier Inc. All rights reserved.
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