Transcription factor networks in erythroid cell and megakaryocyte development - PubMed (original) (raw)

Review

Transcription factor networks in erythroid cell and megakaryocyte development

Louis C Doré et al. Blood. 2011.

Abstract

Erythroid cells and megakaryocytes are derived from a common precursor, the megakaryocyte-erythroid progenitor. Although these 2 closely related hematopoietic cell types share many transcription factors, there are several key differences in their regulatory networks that lead to differential gene expression downstream of the megakaryocyte-erythroid progenitor. With the advent of next-generation sequencing and our ability to precisely define transcription factor chromatin occupancy in vivo on a global scale, we are much closer to understanding how these 2 lineages are specified and in general how transcription factor complexes govern hematopoiesis.

PubMed Disclaimer

Figures

Figure 1

Figure 1

Erythroid cells and megakaryocytes are derived from a common progenitor. The decision of whether the MEP should give rise to red cell or platelet lineages is controlled by an array of transcription factors and microRNAs.

Figure 2

Figure 2

A complex regulatory network controls MEP cell fate. The relative levels of expression of key regulatory factors, including GATA-1, GATA-2, SCL, and PU.1, are predicted to control the output toward erythroid cells (marked by EKLF) or megakaryocytes (marked by Fli-1). Arrows indicate gene activation; and blunted lines, repression.

Similar articles

Cited by

References

    1. Debili N, Coulombel L, Croisille L, et al. Characterization of a bipotent erythro-megakaryocytic progenitor in human bone marrow. Blood. 1996;88(4):1284–1296. - PubMed
    1. Vannucchi AM, Paoletti F, Linari S, et al. Identification and characterization of a bipotent (erythroid and megakaryocytic) cell precursor from the spleen of phenylhydrazine-treated mice. Blood. 2000;95(8):2559–2568. - PubMed
    1. Akashi K, Traver D, Miyamoto T, Weissman IL. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature. 2000;404(6774):193–197. - PubMed
    1. Stachura DL, Chou ST, Weiss MJ. Early block to erythromegakaryocytic development conferred by loss of transcription factor GATA-1. Blood. 2006;107(1):87–97. - PMC - PubMed
    1. Wang X, Crispino JD, Letting DL, Nakazawa M, Poncz M, Blobel GA. Control of megakaryocyte-specific gene expression by GATA-1 and FOG-1: role of Ets transcription factors. EMBO J. 2002;21(19):5225–5234. - PMC - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources