The truth about genetic variation in the serotonin transporter gene and response to stress and medication - PubMed (original) (raw)
Editorial
The truth about genetic variation in the serotonin transporter gene and response to stress and medication
Peter McGuffin et al. Br J Psychiatry. 2011 Jun.
Abstract
The question of whether a functional variant in the promoter of the serotonin transporter gene (5-HTTLPR) influences response to adversity and/or antidepressants has generated great interest and controversy. A review of the literature suggests that the issue is complicated by differences in methodology and sample ethnicity. When these confounders are accounted for, there probably is a real, if small, effect of 5-HTTLPR on response to both serotonin reuptake inhibitors and environmental adversity.
Comment on
- Polymorphism of the 5-HT transporter and response to antidepressants: randomised controlled trial.
Lewis G, Mulligan J, Wiles N, Cowen P, Craddock N, Ikeda M, Grozeva D, Mason V, Nutt D, Sharp D, Tallon D, Thomas L, O'Donovan MC, Peters TJ. Lewis G, et al. Br J Psychiatry. 2011 Jun;198(6):464-71. doi: 10.1192/bjp.bp.110.082727. Epub 2011 Jan 24. Br J Psychiatry. 2011. PMID: 21263010 Clinical Trial.
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