The role of nuclear factor κB in the interferon response - PubMed (original) (raw)

Review

The role of nuclear factor κB in the interferon response

Lawrence M Pfeffer. J Interferon Cytokine Res. 2011 Jul.

Abstract

The nuclear factor κB (NF-κB) transcription factor regulates the expression of genes involved in cell survival and immune responses. We have identified a novel interferon (IFN)-activated signaling pathway that leads to NF-κB activation and demonstrate that a subset of IFN-stimulated genes and microRNAs that play key roles in cellular response to IFN is regulated by NF-κB. This review focuses on the IFN-induced NF-κB activation pathway and the role of NF-κB in the expression of IFN-induced coding and noncoding genes, antiviral activity and apoptosis, and the therapeutic application of IFN in cancer and infectious disease.

PubMed Disclaimer

Figures

FIG. 1.

FIG. 1.

Schematic of microRNA (miRNA) biogenesis.

FIG. 2.

FIG. 2.

Schematic of interferon (IFN)-activated signaling pathways.

References

    1. Au PY. Yeh WC. Physiological roles and mechanisms of signaling by TRAF2 and TRAF5. Adv Exp Med Biol. 2007;597:32–47. - PubMed
    1. Baeuerle PA. IkB-NFkB structures: at the interface of inflammation control. Cell. 1998;95:729–731. - PubMed
    1. Baeurele PA. Baltimore D. IkB: a specific inhibitor of NFkB transcription factor. Science. 1988;242:540–546. - PubMed
    1. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004;116(2):281–297. - PubMed
    1. Beg AA. Baltimore D. An essential role for NF-κB in preventing TNF-α-induced cell death. Science. 1996;274:782–784. - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources