The gene for the human erythropoietin receptor: analysis of the coding sequence and assignment to chromosome 19p - PubMed (original) (raw)
. 1990 Jul 1;76(1):24-30.
Affiliations
- PMID: 2163695
Free article
The gene for the human erythropoietin receptor: analysis of the coding sequence and assignment to chromosome 19p
J C Winkelmann et al. Blood. 1990.
Free article
Abstract
The full-length coding sequence of the human erythropoietin receptor has been assembled from cDNA and genomic DNA. The derived 508 amino acid sequence is 82% identical to the murine erythropoietin (Epo) receptor with one single residue gap in alignment. There is no major structural difference between the human and murine receptor molecules. Nucleotide sequence homology is, as expected, very high within the coding domain. Unexpectedly, there are two distinct, short stretches of 3' untranslated sequence homology between human and murine cDNAs. The functional significance of this sequence conservation is unknown. The human Epo receptor gene is localized to human chromosome 19p by in situ hybridization. This chromosome assignment is confirmed by hybridization to a panel of sorted human chromosomes.
Similar articles
- Genomic organization of the human erythropoietin receptor gene.
Penny LA, Forget BG. Penny LA, et al. Genomics. 1991 Dec;11(4):974-80. doi: 10.1016/0888-7543(91)90022-7. Genomics. 1991. PMID: 1664413 - Cloning of the gene encoding the human erythropoietin receptor.
Maouche L, Tournamille C, Hattab C, Boffa G, Cartron JP, Chrétien S. Maouche L, et al. Blood. 1991 Nov 15;78(10):2557-63. Blood. 1991. PMID: 1668607 - Cloning of the human erythropoietin receptor gene.
Noguchi CT, Bae KS, Chin K, Wada Y, Schechter AN, Hankins WD. Noguchi CT, et al. Blood. 1991 Nov 15;78(10):2548-56. Blood. 1991. PMID: 1668606 - Cloning and chromosome mapping of human retinoid X receptor beta: selective amino acid sequence conservation of a nuclear hormone receptor in mammals.
Fleischhauer K, McBride OW, DiSanto JP, Ozato K, Yang SY. Fleischhauer K, et al. Hum Genet. 1993 Jan;90(5):505-10. doi: 10.1007/BF00217449. Hum Genet. 1993. PMID: 8381386 - Assignment of the erythropoietin receptor (EPOR) gene to mouse chromosome 9 and human chromosome 19.
Budarf M, Huebner K, Emanuel B, Croce CM, Copeland NG, Jenkins NA, D'Andrea AD. Budarf M, et al. Genomics. 1990 Nov;8(3):575-8. doi: 10.1016/0888-7543(90)90047-x. Genomics. 1990. PMID: 1962754
Cited by
- Erythropoietin and cancer: the unintended consequences of anemia correction.
Debeljak N, Solár P, Sytkowski AJ. Debeljak N, et al. Front Immunol. 2014 Nov 11;5:563. doi: 10.3389/fimmu.2014.00563. eCollection 2014. Front Immunol. 2014. PMID: 25426117 Free PMC article. Review. - The effect of erythropoietin on normal and neoplastic cells.
Elliott S, Sinclair AM. Elliott S, et al. Biologics. 2012;6:163-89. doi: 10.2147/BTT.S32281. Epub 2012 Jun 27. Biologics. 2012. PMID: 22848149 Free PMC article. - Erythropoietin: recent developments in the treatment of spinal cord injury.
Carelli S, Marfia G, Di Giulio AM, Ghilardi G, Gorio A. Carelli S, et al. Neurol Res Int. 2011;2011:453179. doi: 10.1155/2011/453179. Epub 2011 Jul 4. Neurol Res Int. 2011. PMID: 21766022 Free PMC article. - Soluble erythropoietin receptor contributes to erythropoietin resistance in end-stage renal disease.
Khankin EV, Mutter WP, Tamez H, Yuan HT, Karumanchi SA, Thadhani R. Khankin EV, et al. PLoS One. 2010 Feb 16;5(2):e9246. doi: 10.1371/journal.pone.0009246. PLoS One. 2010. PMID: 20169072 Free PMC article. - Erythropoietin in spinal cord injury.
Matis GK, Birbilis TA. Matis GK, et al. Eur Spine J. 2009 Mar;18(3):314-23. doi: 10.1007/s00586-008-0829-0. Epub 2008 Nov 22. Eur Spine J. 2009. PMID: 19030901 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous