Carbapenem-resistant Enterobacteriaceae: epidemiology and prevention - PubMed (original) (raw)

Review

Carbapenem-resistant Enterobacteriaceae: epidemiology and prevention

Neil Gupta et al. Clin Infect Dis. 2011.

Abstract

Over the past 10 years, dissemination of Klebsiella pneumoniae carbapenemase (KPC) has led to an increase in the prevalence of carbapenem-resistant Enterobacteriaceae (CRE) in the United States. Infections caused by CRE have limited treatment options and have been associated with high mortality rates. In the previous year, other carbapenemase subtypes, including New Delhi metallo-β-lactamase, have been identified among Enterobacteriaceae in the United States. Like KPC, these enzymes are frequently found on mobile genetic elements and have the potential to spread widely. As a result, preventing both CRE transmission and CRE infections have become important public health objectives. This review describes the current epidemiology of CRE in the United States and highlights important prevention strategies.

© The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.

PubMed Disclaimer

Similar articles

• Notes from the Field: Carbapenem-resistant Enterobacteriaceae Producing OXA-48-like Carbapenemases--United States, 2010-2015.
  Lyman M, Walters M, Lonsway D, Rasheed K, Limbago B, Kallen A. Lyman M, et al. MMWR Morb Mortal Wkly Rep. 2015 Dec 4;64(47):1315-6. doi: 10.15585/mmwr.mm6447a3. MMWR Morb Mortal Wkly Rep. 2015. PMID: 26633574
• Improved Phenotype-Based Definition for Identifying Carbapenemase Producers among Carbapenem-Resistant Enterobacteriaceae.
  Chea N, Bulens SN, Kongphet-Tran T, Lynfield R, Shaw KM, Vagnone PS, Kainer MA, Muleta DB, Wilson L, Vaeth E, Dumyati G, Concannon C, Phipps EC, Culbreath K, Janelle SJ, Bamberg WM, Guh AY, Limbago B, Kallen AJ. Chea N, et al. Emerg Infect Dis. 2015 Sep;21(9):1611-6. doi: 10.3201/eid2109.150198. Emerg Infect Dis. 2015. PMID: 26290955 Free PMC article.
• New Delhi Metallo-beta lactamase (NDM-1) in Enterobacteriaceae: treatment options with carbapenems compromised.
  Deshpande P, Rodrigues C, Shetty A, Kapadia F, Hedge A, Soman R. Deshpande P, et al. J Assoc Physicians India. 2010 Mar;58:147-9. J Assoc Physicians India. 2010. PMID: 20848811
• Carbapenemase-producing Enterobacteriaceae: overview of a major public health challenge.
  Nordmann P. Nordmann P. Med Mal Infect. 2014 Feb;44(2):51-6. doi: 10.1016/j.medmal.2013.11.007. Epub 2013 Dec 18. Med Mal Infect. 2014. PMID: 24360201 Review.
• [KPC carbapenemases: what is at stake in clinical microbiology?].
  Cuzon G, Naas T, Nordmann P. Cuzon G, et al. Pathol Biol (Paris). 2010 Feb;58(1):39-45. doi: 10.1016/j.patbio.2009.07.026. Epub 2009 Oct 24. Pathol Biol (Paris). 2010. PMID: 19854586 Review. French.

Cited by

• Ready for a world without antibiotics? The Pensières Antibiotic Resistance Call to Action.
  Carlet J, Jarlier V, Harbarth S, Voss A, Goossens H, Pittet D; Participants of the 3rd World Healthcare-Associated Infections Forum. Carlet J, et al. Antimicrob Resist Infect Control. 2012 Feb 14;1(1):11. doi: 10.1186/2047-2994-1-11. Antimicrob Resist Infect Control. 2012. PMID: 22958833 Free PMC article.
• Resensitizing carbapenem- and colistin-resistant bacteria to antibiotics using auranofin.
  Sun H, Zhang Q, Wang R, Wang H, Wong YT, Wang M, Hao Q, Yan A, Kao RY, Ho PL, Li H. Sun H, et al. Nat Commun. 2020 Oct 16;11(1):5263. doi: 10.1038/s41467-020-18939-y. Nat Commun. 2020. PMID: 33067430 Free PMC article.
• Emergence and transmission of the high-risk ST78 clone of OXA-48-producing Enterobacter hormaechei in a single hospital in Taiwan.
  Chen CM, Tang HL, Chen YT, Ke SC, Lin YP, Chen BH, Teng RH, Chiou CS, Lu MC, Lai YC. Chen CM, et al. Emerg Microbes Infect. 2024 Dec;13(1):2404165. doi: 10.1080/22221751.2024.2404165. Epub 2024 Sep 22. Emerg Microbes Infect. 2024. PMID: 39258852 Free PMC article.
• Characterization of porin expression in Klebsiella pneumoniae Carbapenemase (KPC)-producing K. pneumoniae identifies isolates most susceptible to the combination of colistin and carbapenems.
  Hong JH, Clancy CJ, Cheng S, Shields RK, Chen L, Doi Y, Zhao Y, Perlin DS, Kreiswirth BN, Nguyen MH. Hong JH, et al. Antimicrob Agents Chemother. 2013 May;57(5):2147-53. doi: 10.1128/AAC.02411-12. Epub 2013 Mar 4. Antimicrob Agents Chemother. 2013. PMID: 23459476 Free PMC article.
• Insights into colistin-mediated fluorescence labelling of bacterial LPS.
  Mandal S, Patra D, Mandal S, Das GK, Sahoo P. Mandal S, et al. RSC Adv. 2024 Jan 17;14(4):2770-2777. doi: 10.1039/d3ra07107c. eCollection 2024 Jan 10. RSC Adv. 2024. PMID: 38234867 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.
  • Silverchair Information Systems

• Other Literature Sources

  • The Lens - Patent Citations Database

• Research Materials

  • NCI CPTC Antibody Characterization Program

• Miscellaneous

  • NCI CPTAC Assay Portal