Influence of chromosome 22q11.2 microdeletion on postoperative calcium level after cardiac-correction surgery - PubMed (original) (raw)
Comparative Study
doi: 10.1007/s00246-011-0012-y. Epub 2011 Jun 16.
Haitao Gu, Dongjing Wang, Chi Yang, Zhengfeng Xu, Hua Jing, Yongzhong Jiang, Yibing Ding, Huacheng Hou, Zhijuan Ge, Shilin Chen, Xuming Mo, Long Yi
Affiliations
- PMID: 21678063
- DOI: 10.1007/s00246-011-0012-y
Comparative Study
Influence of chromosome 22q11.2 microdeletion on postoperative calcium level after cardiac-correction surgery
Li Shen et al. Pediatr Cardiol. 2011 Oct.
Abstract
One of the most common constitutional chromosomal abnormalities, 22q11.2 microdeletion (del22q11.2) syndrome has diverse medical complications, such as congenital heart defect, hypocalcaemia, and immune deficiency, which require coordinated multidisciplinary care. Until now, the natural history of hypocalcaemia in chromosome del22q11.2 syndrome had been only partly documented, but there has been limited recognition of the importance of calcium status during the postoperative period when altered calcium status may be associated with serious complications. The goals of our study were (1) to delineate the clinical characteristics of serum calcium in patients with del22q11.2 during the postoperative period and (2) to make recommendations for the investigation and management of del22q11.2 patients after cardiac correction. This study included 22 children diagnosed with del22q11.2 syndrome and 110 children without del22q11.2 syndrome from Nanjing Children's Hospital. Clinical examinations and blood ionized calcium testing were reviewed retrospectively. A comparative study of postoperative calcium levels and complications of del22q11.2 patients with nondeletion patients was performed. Association between postoperative hypocalcaemia and adverse incidents after cardiac correction was also examined. Postoperative hypocalcaemia was observed among 86.4% of del22q11.2 patients and among only 47.3% of nondeletion subjects. The difference was statistically significant (P = 0.0017). Patients with del22q11.2 syndrome also had a much sharper decrease in serum calcium levels during the first 6 h after surgery than nondeletion patients. Postoperative clinical analysis showed that del22q11.2 patients with hypocalcaemia experience more postoperative complications (18 of 19) and greater mortality (5 of 19) after cardiac correction than del22q11.2 patients without normal calcium levels and nondeletion patients. Del22q11.2 children have high susceptibility of hypocalcaemia during the postoperative period, and this low calcium status after cardiac correction may be associated with significant risk of postoperative complications and mortality in patients with del22q11.2.
Similar articles
- The Impact of 22q11.2 Microdeletion on Cardiac Surgery Postoperative Outcome.
Cuturilo G, Drakulic D, Jovanovic I, Ilic S, Kalanj J, Vulicevic I, Raus M, Skoric D, Mijovic M, Medjo B, Rsovac S, Stevanovic M. Cuturilo G, et al. Pediatr Cardiol. 2017 Dec;38(8):1680-1685. doi: 10.1007/s00246-017-1713-7. Epub 2017 Sep 22. Pediatr Cardiol. 2017. PMID: 28940032 - Impact of 22q11.2 deletion on the postoperative course of children after cardiac surgery.
McDonald R, Dodgen A, Goyal S, Gossett JM, Shinkawa T, Uppu SC, Blanco C, Garcia X, Bhutta AT, Imamura M, Gupta P. McDonald R, et al. Pediatr Cardiol. 2013 Feb;34(2):341-7. doi: 10.1007/s00246-012-0454-x. Epub 2012 Aug 3. Pediatr Cardiol. 2013. PMID: 22864648 - Chromosome 22q11.2 microdeletion in children with conotruncal heart defects: frequency, associated cardiovascular anomalies, and outcome following cardiac surgery.
Ziolkowska L, Kawalec W, Turska-Kmiec A, Krajewska-Walasek M, Brzezinska-Rajszys G, Daszkowska J, Maruszewski B, Burczynski P. Ziolkowska L, et al. Eur J Pediatr. 2008 Oct;167(10):1135-40. doi: 10.1007/s00431-007-0645-2. Epub 2008 Jan 3. Eur J Pediatr. 2008. PMID: 18172682 - Congenital heart defects in patients with DiGeorge/velocardiofacial syndrome and del22q11.
Marino B, Digilio MC, Toscano A, Giannotti A, Dallapiccola B. Marino B, et al. Genet Couns. 1999;10(1):25-33. Genet Couns. 1999. PMID: 10191426 Review. - CATCH 22 syndrome: report of 7 infants with follow-up data and review of the recent advancements in the genetic knowledge of the locus 22q11.
Sergi C, Serpi M, Müller-Navia J, Schnabel PA, Hagl S, Otto HF, Ulmer HE. Sergi C, et al. Pathologica. 1999 Jun;91(3):166-72. Pathologica. 1999. PMID: 10536461 Review.
Cited by
- Postoperative Hypocalcemia following Non-Cardiac Surgical Procedures in Children with 22q11.2 Deletion Syndrome.
Arganbright JM, Tracy M, Feldt M, Narayanan S, Mahadev A, Noel-MacDonnell J. Arganbright JM, et al. Genes (Basel). 2022 Oct 20;13(10):1905. doi: 10.3390/genes13101905. Genes (Basel). 2022. PMID: 36292790 Free PMC article. - 22q11.2 Deletion Syndrome: Impact of Genetics in the Treatment of Conotruncal Heart Defects.
Putotto C, Pugnaloni F, Unolt M, Maiolo S, Trezzi M, Digilio MC, Cirillo A, Limongelli G, Marino B, Calcagni G, Versacci P. Putotto C, et al. Children (Basel). 2022 May 25;9(6):772. doi: 10.3390/children9060772. Children (Basel). 2022. PMID: 35740709 Free PMC article. Review. - Genetic abnormalities/syndromes significantly impact perioperative outcomes of conotruncal heart defects.
Lahiri S, Gil W, Daria S, Joshua G, Parul J, Redmond B, Elizabeth W. Lahiri S, et al. Ann Pediatr Cardiol. 2020 Jan-Mar;13(1):38-45. doi: 10.4103/apc.APC_51_19. Epub 2019 Oct 9. Ann Pediatr Cardiol. 2020. PMID: 32030034 Free PMC article. - Association of hypocalcemia with congenital heart disease in 22q11.2 deletion syndrome.
Rayannavar A, Levitt Katz LE, Crowley TB, Lessig M, Grand K, Goldmuntz E, Zackai EH, McDonald-McGinn DM. Rayannavar A, et al. Am J Med Genet A. 2018 Oct;176(10):2099-2103. doi: 10.1002/ajmg.a.40495. Epub 2018 Oct 1. Am J Med Genet A. 2018. PMID: 30277015 Free PMC article. - The Impact of 22q11.2 Microdeletion on Cardiac Surgery Postoperative Outcome.
Cuturilo G, Drakulic D, Jovanovic I, Ilic S, Kalanj J, Vulicevic I, Raus M, Skoric D, Mijovic M, Medjo B, Rsovac S, Stevanovic M. Cuturilo G, et al. Pediatr Cardiol. 2017 Dec;38(8):1680-1685. doi: 10.1007/s00246-017-1713-7. Epub 2017 Sep 22. Pediatr Cardiol. 2017. PMID: 28940032
References
- Lancet. 2007 Oct 20;370(9596):1443-52 - PubMed
- J Pediatr Hematol Oncol. 2008 Aug;30(8):612-7 - PubMed
- Electrophoresis. 2009 Feb;30(3):465-71 - PubMed
- Arch Dis Child. 1998 Oct;79(4):348-51 - PubMed
- Arch Dis Child. 2003 Jun;88(6):520-2 - PubMed
Publication types
MeSH terms
Substances
Supplementary concepts
LinkOut - more resources
Full Text Sources
Medical