Incidence of type 1 diabetes in Sweden among individuals aged 0-34 years, 1983-2007: an analysis of time trends - PubMed (original) (raw)
Incidence of type 1 diabetes in Sweden among individuals aged 0-34 years, 1983-2007: an analysis of time trends
Gisela G Dahlquist et al. Diabetes Care. 2011 Aug.
Abstract
Objective: To clarify whether the increase in childhood type 1 diabetes is mirrored by a decrease in older age-groups, resulting in younger age at diagnosis.
Research design and methods: We used data from two prospective research registers, the Swedish Childhood Diabetes Register, which included case subjects aged 0-14.9 years at diagnosis, and the Diabetes in Sweden Study, which included case subjects aged 15-34.9 years at diagnosis, covering birth cohorts between 1948 and 2007. The total database included 20,249 individuals with diabetes diagnosed between 1983 and 2007. Incidence rates over time were analyzed using Poisson regression models.
Results: The overall yearly incidence rose to a peak of 42.3 per 100,000 person-years in male subjects aged 10-14 years and to a peak of 37.1 per 100,000 person-years in female subjects aged 5-9 years and decreased thereafter. There was a significant increase by calendar year in both sexes in the three age-groups <15 years; however, there were significant decreases in the older age-groups (25- to 29-years and 30- to 34-years age-groups). Poisson regression analyses showed that a cohort effect seemed to dominate over a time-period effect.
Conclusions: Twenty-five years of prospective nationwide incidence registration demonstrates a clear shift to younger age at onset rather than a uniform increase in incidence rates across all age-groups. The dominance of cohort effects over period effects suggests that exposures affecting young children may be responsible for the increasing incidence in the younger age-groups.
Figures
Figure 1
Change in average age at diagnosis by time period and 95% CI.
Figure 2
Observed incidence rates by 5-year birth cohort (A) and fitted incidence rates obtained from the age-cohort model (B) for male and female subjects, respectively.
Similar articles
- The incidence of Type I diabetes has not increased but shifted to a younger age at diagnosis in the 0-34 years group in Sweden 1983-1998.
Pundziute-Lyckå A, Dahlquist G, Nyström L, Arnqvist H, Björk E, Blohmé G, Bolinder J, Eriksson JW, Sundkvist G, Ostman J; Swedish Childhood Diabetes Study Group. Pundziute-Lyckå A, et al. Diabetologia. 2002 Jun;45(6):783-91. doi: 10.1007/s00125-002-0845-2. Epub 2002 May 8. Diabetologia. 2002. PMID: 12107721 - The incidence of diabetes among 0-34 year olds in Sweden: new data and better methods.
Rawshani A, Landin-Olsson M, Svensson AM, Nyström L, Arnqvist HJ, Bolinder J, Gudbjörnsdottir S. Rawshani A, et al. Diabetologia. 2014 Jul;57(7):1375-81. doi: 10.1007/s00125-014-3225-9. Epub 2014 Apr 9. Diabetologia. 2014. PMID: 24710965 Free PMC article. - Time trends and gender differences in incidence and prevalence of type 1 diabetes in Sweden.
Wändell PE, Carlsson AC. Wändell PE, et al. Curr Diabetes Rev. 2013 Jul;9(4):342-9. doi: 10.2174/15733998113099990064. Curr Diabetes Rev. 2013. PMID: 23721159 Review. - ["Constantly rising or peaks and plateaus?" Incidence of childhood type 1 diabetes in Hungary (1989-2009)].
Gyürüs E, Patterson C, Soltész G. Gyürüs E, et al. Orv Hetil. 2011 Oct 16;152(42):1692-7. doi: 10.1556/OH.2011.29210. Orv Hetil. 2011. PMID: 21979222 Review. Hungarian.
Cited by
- Universal screening for early detection of chronic autoimmune, metabolic and cardiovascular diseases in the general population using capillary blood (UNISCREEN): low-risk interventional, single-centre, pilot study protocol.
Merolla A, De Lorenzo R, Ferrannini G, Renzi C, Ulivi F, Bazzigaluppi E, Lampasona V, Bosi E. Merolla A, et al. BMJ Open. 2024 Mar 5;14(3):e078983. doi: 10.1136/bmjopen-2023-078983. BMJ Open. 2024. PMID: 38448070 Free PMC article. - Human immune phenotyping reveals accelerated aging in type 1 diabetes.
Shapiro MR, Dong X, Perry DJ, McNichols JM, Thirawatananond P, Posgai AL, Peters LD, Motwani K, Musca RS, Muir A, Concannon P, Jacobsen LM, Mathews CE, Wasserfall CH, Haller MJ, Schatz DA, Atkinson MA, Brusko MA, Bacher R, Brusko TM. Shapiro MR, et al. JCI Insight. 2023 Sep 8;8(17):e170767. doi: 10.1172/jci.insight.170767. JCI Insight. 2023. PMID: 37498686 Free PMC article. - Low maternal education increases the risk of Type 1 Diabetes, but not other autoimmune diseases: a mediating role of childhood BMI and exposure to serious life events.
White PA, Faresjö T, Jones MP, Ludvigsson J. White PA, et al. Sci Rep. 2023 Apr 15;13(1):6166. doi: 10.1038/s41598-023-32869-x. Sci Rep. 2023. PMID: 37061552 Free PMC article. - Protocol for a nested case-control study design for omics investigations in the Environmental Determinants of Islet Autoimmunity cohort.
Oakey H, Giles LC, Thomson RL, Lê Cao KA, Ashwood P, Brown JD, Knight EJ, Barry SC, Craig ME, Colman PG, Davis EA, Hamilton-Williams EE, Harrison LC, Haynes A, Kim KW, Mallitt KA, McGorm K, Morahan G, Rawlinson WD, Sinnott RO, Soldatos G, Wentworth JM, Couper JJ, Penno MAS; ENDIA Study Group. Oakey H, et al. Ann Med. 2023 Dec;55(1):2198255. doi: 10.1080/07853890.2023.2198255. Ann Med. 2023. PMID: 37043275 Free PMC article. - Clinical and biochemical profile of childhood-adolescent-onset type 1 diabetes and adult-onset type 1 diabetes among Asian Indians.
Mohan V, Uma Sankari G, Amutha A, Anjana RM, Jeba Rani S, Unnikrishnan R, Venkatesan U, Shanthi Rani CS. Mohan V, et al. Acta Diabetol. 2023 Apr;60(4):579-586. doi: 10.1007/s00592-023-02034-x. Epub 2023 Jan 26. Acta Diabetol. 2023. PMID: 36700996
References
- Onkamo P, Väänänen S, Karvonen M, Tuomilehto J. Worldwide increase in incidence of type I diabetes: the analysis of the data on published incidence trends. Diabetologia 1999;42:1395–1403 [Erratum in Diabetologia 1999;43:685] - PubMed
- Patterson C, Dahlquist G, Gyürus E, Green A, Soltesz G; the EURODIAB Study Group. Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-2020: a multicenter prospective registration study. Lancet 2009;373:2027–2033 - PubMed
- Dahlquist G, Mustonen L; Swedish Childhood Diabetes Study Group. Analysis of 20 years of prospective registration of childhood onset diabetes time trends and birth cohort effects. Acta Paediatr 2000;89:1231–1237 - PubMed
- Pundziute-Lyckå A, Dahlquist G, Nyström L, et al. ; Swedish Childhood Diabetes Study Group. The incidence of type I diabetes has not increased but shifted to a younger age at diagnosis in the 0-34 years group in Sweden 1983-1998. Diabetologia 2002;45:783–791 - PubMed
- Östman J, Lönnberg G, Arnqvist HJ, et al. . Gender differences and temporal variation in the incidence of type 1 diabetes: results of 8012 cases in the nationwide Diabetes Incidence Study in Sweden 1983-2002. J Intern Med 2008;263:386–394 - PubMed
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical