The global epidemiology of hepatocellular carcinoma: present and future - PubMed (original) (raw)

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The global epidemiology of hepatocellular carcinoma: present and future

Katherine A McGlynn et al. Clin Liver Dis. 2011 May.

Abstract

The global risk of hepatocellular carcinoma (HCC) has been largely driven by hepatitis B virus (HBV) infection for the past century, along with hepatitis C virus (HCV), aflatoxin, excessive alcohol consumption, and obesity/diabetes. The dominant effect of HBV on global HCC risk should decline as the population vaccinated against HBV grows older. Infection with HCV is also expected to decline. Projections of HCV-related HCC rates remaining high for another 30 years may be overly pessimistic. Alcohol may be less of a factor in HCC in coming years. However, obesity and diabetes may become even more important risk factors for HCC.

Copyright © 2011. Published by Elsevier Inc.

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Figures

Figure 1

Figure 1

Age-adjusted incidence rates per 100,000 of liver cancer among males by region. Cancer Incidence in 5 Continents. Age adjusted to world standard.

Figure 2

Figure 2

Age-adjusted incidence rates per 100,000 of liver cancer among selected Chinese populations. Cancer Incidence in 5 Continents. Age adjusted to world standard.

Figure 3

Figure 3

Global prevalence of chronic infection with hepatitis B virus, 2006. Centers for Disease Control:

http://wwwnc.cdc.gov/travel/yellowbook/2010/chapter-5/hepatitis-c.aspx

Figure 4

Figure 4

Global prevalence of hepatitis C infection. Centers for Disease Control:

http://wwwnc.cdc.gov/travel/yellowbook/2010/chapter-5/hepatitis-c.aspx

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