Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile - PubMed (original) (raw)

• Genetic variation near IRS1 is associated with adiposity and a favorable metabolic profile in U.S. Hispanics/Latinos.
  Qi Q, Gogarten SM, Emery LS, Louie T, Stilp A, Cai J, Schneiderman N, Avilés-Santa ML, Kaplan RC, North KE, Laurie CC, Loos RJ, Isasi CR. Qi Q, et al. Obesity (Silver Spring). 2016 Nov;24(11):2407-2413. doi: 10.1002/oby.21624. Epub 2016 Sep 24. Obesity (Silver Spring). 2016. PMID: 27663718 Free PMC article.
• INSIG2 gene polymorphism is associated with increased subcutaneous fat in women and poor response to resistance training in men.
  Orkunoglu-Suer FE, Gordish-Dressman H, Clarkson PM, Thompson PD, Angelopoulos TJ, Gordon PM, Moyna NM, Pescatello LS, Visich PS, Zoeller RF, Harmon B, Seip RL, Hoffman EP, Devaney JM. Orkunoglu-Suer FE, et al. BMC Med Genet. 2008 Dec 23;9:117. doi: 10.1186/1471-2350-9-117. BMC Med Genet. 2008. PMID: 19105843 Free PMC article.
• Common variants near MC4R are associated with fat mass, weight and risk of obesity.
  Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, Prokopenko I, Inouye M, Freathy RM, Attwood AP, Beckmann JS, Berndt SI; Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial; Jacobs KB, Chanock SJ, Hayes RB, Bergmann S, Bennett AJ, Bingham SA, Bochud M, Brown M, Cauchi S, Connell JM, Cooper C, Smith GD, Day I, Dina C, De S, Dermitzakis ET, Doney AS, Elliott KS, Elliott P, Evans DM, Sadaf Farooqi I, Froguel P, Ghori J, Groves CJ, Gwilliam R, Hadley D, Hall AS, Hattersley AT, Hebebrand J, Heid IM; KORA; Lamina C, Gieger C, Illig T, Meitinger T, Wichmann HE, Herrera B, Hinney A, Hunt SE, Jarvelin MR, Johnson T, Jolley JD, Karpe F, Keniry A, Khaw KT, Luben RN, Mangino M, Marchini J, McArdle WL, McGinnis R, Meyre D, Munroe PB, Morris AD, Ness AR, Neville MJ, Nica AC, Ong KK, O'Rahilly S, Owen KR, Palmer CN, Papadakis K, Potter S, Pouta A, Qi L; Nurses' Health Study; Randall JC, Rayner NW, Ring SM, Sandhu MS, Scherag A, Sims MA, Song K, Soranzo N, Speliotes EK; Diabetes Genetics Initiative; Syddall HE, Teichmann SA, Timpson NJ, Tobias JH, Uda M; SardiNIA Study; Vogel CI, Wallace C, Waterworth DM, Weedon MN; Wellcome Trust Case Control Consortium; Willer CJ; FUSION; Wraig… See abstract for full author list ➔ Loos RJ, et al. Nat Genet. 2008 Jun;40(6):768-75. doi: 10.1038/ng.140. Epub 2008 May 4. Nat Genet. 2008. PMID: 18454148 Free PMC article.
• IRS1 DNA promoter methylation and expression in human adipose tissue are related to fat distribution and metabolic traits.
  Rohde K, Klös M, Hopp L, Liu X, Keller M, Stumvoll M, Dietrich A, Schön MR, Gärtner D, Lohmann T, Dreßler M, Kovacs P, Binder H, Blüher M, Böttcher Y. Rohde K, et al. Sci Rep. 2017 Sep 28;7(1):12369. doi: 10.1038/s41598-017-12393-5. Sci Rep. 2017. PMID: 28959056 Free PMC article.
• The genetics of adiposity.
  Loos RJ. Loos RJ. Curr Opin Genet Dev. 2018 Jun;50:86-95. doi: 10.1016/j.gde.2018.02.009. Epub 2018 Mar 9. Curr Opin Genet Dev. 2018. PMID: 29529423 Free PMC article. Review.