Factors in the surgical management of primary eccrine porocarcinoma: prognostic histological factors can guide the surgical procedure - PubMed (original) (raw)
Factors in the surgical management of primary eccrine porocarcinoma: prognostic histological factors can guide the surgical procedure
E Belin et al. Br J Dermatol. 2011 Nov.
Abstract
Background: Primary eccrine porocarcinoma is a rare cutaneous neoplasm and there is no consensus concerning its surgical management.
Objectives: To conduct a retrospective analysis of all the cases of eccrine porocarcinoma seen in our hospital in order to identify prognostic factors.
Methods: Clinical data were retrieved from the patients' files. Each histological sample was reviewed by the pathologist and classified into three eccrine porocarcinoma subtypes: 'infiltrative', 'pushing' and 'pagetoid' eccrine porocarcinoma, according to Robson's criteria. Statistical methods were used to estimate the recurrence risk.
Results: Twenty-four patients were included. The surgical margins realized were ≥ 2 cm or < 2 cm in six and 13 patients, respectively, and slow Mohs procedure was performed in two patients. Ten, seven and two patients presented with 'infiltrative', 'pushing' or 'pagetoid' eccrine porocarcinoma, respectively. Eight patients (of 23) experienced recurrences (35%). The recurrence risk was linked to the histological subtype: two out of two pagetoid eccrine porocarcinoma, four out of 10 'infiltrative' and none of seven 'pushing' eccrine porocarcinoma recurred (P=0·026). The recurrence risk was not associated with epidermal growth factor receptor status, nor the margin realized.
Conclusions: The recurrence risk of 'pushing' eccrine porocarcinoma is significantly lower than for 'infiltrative' eccrine porocarcinoma. Based on these considerations, a decisional algorithm might be proposed: first step, excisional biopsy of the primary eccrine porocarcinoma and identification of the histological subtype; second step, infiltrative or pagetoid porocarcinoma should be excised with an additional modified micrographic Mohs procedure, while no additional surgery is needed for 'pushing' eccrine porocarcinoma if the first excisional biopsy is complete. Although demonstrated in a limited case series, the histological subtype might guide the surgical management of primary eccrine porocarcinoma.
© 2011 The Authors. BJD © 2011 British Association of Dermatologists.
Similar articles
- [Primary eccrine porocarcinoma: a clinicopathological study of 50 cases].
Skowron F, Poulhalon N, Balme B, Touzet S, Thomas L. Skowron F, et al. Ann Dermatol Venereol. 2014 Apr;141(4):258-64. doi: 10.1016/j.annder.2013.10.047. Epub 2013 Dec 5. Ann Dermatol Venereol. 2014. PMID: 24703639 French. - Mohs micrographic surgery for eccrine porocarcinoma: an update and review of the literature.
Song SS, Wu Lee W, Hamman MS, Jiang SI. Song SS, et al. Dermatol Surg. 2015 Mar;41(3):301-6. doi: 10.1097/DSS.0000000000000286. Dermatol Surg. 2015. PMID: 25742554 Review. - Primary eccrine porocarcinoma of the finger with transit forearm and axillary metastasis.
Bhat W, Akhtar S, Khotwal A, Platt AJ. Bhat W, et al. Ann Plast Surg. 2011 Apr;66(4):344-6. doi: 10.1097/SAP.0b013e3181e35c8d. Ann Plast Surg. 2011. PMID: 21042176 - Metastatic eccrine porocarcinoma after Mohs micrographic surgery: a case report.
Vleugels FR, Girouard SD, Schmults CD, Ng AK, Russell SE, Wang LC, Buzney EA. Vleugels FR, et al. J Clin Oncol. 2012 Jul 20;30(21):e188-91. doi: 10.1200/JCO.2011.40.6843. Epub 2012 Jun 11. J Clin Oncol. 2012. PMID: 22689795 No abstract available. - Treatment of eccrine porocarcinoma with Mohs micrographic surgery: a cases series and literature review.
Tidwell WJ, Mayer JE, Malone J, Schadt C, Brown T. Tidwell WJ, et al. Int J Dermatol. 2015 Sep;54(9):1078-83. doi: 10.1111/ijd.12997. Epub 2015 Jul 23. Int J Dermatol. 2015. PMID: 26205087 Review.
Cited by
- Navigating Head and Neck Porocarcinoma: Systematic Review with Special Emphasis on Surgical Safety Margins.
Kučinskaitė A, Ulianskaitė G, Pamedys J, Stundys D. Kučinskaitė A, et al. Cancers (Basel). 2024 Mar 24;16(7):1264. doi: 10.3390/cancers16071264. Cancers (Basel). 2024. PMID: 38610942 Free PMC article. Review. - Eccrine Poroma: Pathogenesis, New Diagnostic Tools and Association with Porocarcinoma-A Review.
Kyrmanidou E, Fotiadou C, Kemanetzi C, Trakatelli MG, Trigoni A, Patsatsi A, Apalla Z, Lazaridou E. Kyrmanidou E, et al. Diagnostics (Basel). 2023 Aug 16;13(16):2689. doi: 10.3390/diagnostics13162689. Diagnostics (Basel). 2023. PMID: 37627947 Free PMC article. Review. - Porocarcinoma Concurrent with Psoriasis Vulgaris: The First Report.
Ehara Y, Goto H, Ozaki K, Yoshida Y. Ehara Y, et al. Yonago Acta Med. 2023 Jul 25;66(3):382-384. doi: 10.33160/yam.2023.08.005. eCollection 2023 Aug. Yonago Acta Med. 2023. PMID: 37621981 Free PMC article. - A patient with porocarcinoma of the lower extremity and lung metastasis: a rare case report.
Zein AFMZ, Luthfi M, Putro WA, Nurbaiti N. Zein AFMZ, et al. Med Pharm Rep. 2023 Jul;96(3):318-322. doi: 10.15386/mpr-2387. Epub 2023 Jul 27. Med Pharm Rep. 2023. PMID: 37577018 Free PMC article. - Eccrine Porocarcinoma: Clinical and Histopathological Study of 14 Patients with Special Emphasis on Sentinel Lymph Node Biopsy.
Meriläinen AS, Von Willenbrand-Bäckmann M, Sihto H, Koljonen V. Meriläinen AS, et al. Acta Derm Venereol. 2023 Jul 13;103:adv11649. doi: 10.2340/actadv.v103.11649. Acta Derm Venereol. 2023. PMID: 37448211 Free PMC article.
MeSH terms
LinkOut - more resources
Full Text Sources
Research Materials