Association between insulin resistance and lean mass loss and fat mass gain in older men without diabetes mellitus - PubMed (original) (raw)

Association between insulin resistance and lean mass loss and fat mass gain in older men without diabetes mellitus

Christine G Lee et al. J Am Geriatr Soc. 2011 Jul.

Abstract

Objectives: To examine the associations between insulin resistance and changes in body composition in older men without diabetes mellitus.

Design: Longitudinal cohort study of older men participating in the Osteoporotic Fractures in Men (MrOS) study.

Setting: Six U.S. clinical centers.

Participants: Three thousand one hundred thirty-two ambulatory men aged 65 and older at baseline.

Measurements: Baseline insulin resistance was calculated for men without diabetes mellitus using the homeostasis model assessment of insulin resistance (HOMA-IR). Total lean, appendicular lean, total fat, and truncal fat mass were measured using dual energy X-ray absorptiometry scans at baseline and 4.6 ± 0.3 years later in 3,132 men with HOMA-IR measurements.

Results: There was greater loss of weight, total lean mass, and appendicular lean mass and less gain in total fat mass and truncal fat mass with increasing quartiles of HOMA-IR (P<.001 for trend). Insulin-resistant men in the highest quartile had higher odds of 5% or more loss of weight (odds ratio (OR)=1.88, 95% confidence interval (CI)=1.46-2.43), total lean mass (OR=2.09, 95% CI=1.60-2.73) and appendicular lean mass (OR=1.57, 95% CI=1.27-1.95) and lower odds of 5% or more gain in total fat mass (OR=0.56, 95% CI=0.45-0.68) and truncal fat mass (OR=0.52, 95% CI=0.42-0.64) than those in the lowest quartile. These findings remained significant after accounting for age, site, baseline weight, physical activity, and change in physical activity. These associations were also independent of other metabolic syndrome features and medications.

Conclusion: Greater lean mass loss and lower fat mass gain occurred in insulin-resistant men without diabetes mellitus than in insulin-sensitive men. Insulin resistance may accelerate age-related sarcopenia.

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Conflict of interest statement

Conflict of Interest: Dr. Cawthon has served as a consultant to Amgen. All other authors have no conflict of interest or financial disclosure to declare.

References

1. Paradisi G, Smith L, Burtner C, et al. Dual energy X-ray absorptiometry assessment of fat mass distribution and its association with the insulin resistance syndrome. Diabetes Care. 1999;22:1310–1317. - PubMed
1. Fink RI, Kolterman OG, Griffin J, et al. Mechanisms of insulin resistance in aging. J Clin Invest. 1983;71:1523–1535. - PMC - PubMed
1. Cowie CC, Rust KF, Ford ES, et al. Full accounting of diabetes and pre-diabetes in the U.S. population in 1988–1994 and 2005–2006. Diabetes Care. 2009;32:287–294. - PMC - PubMed
1. Magkos F, Wang X, Mittendorfer B. Metabolic actions of insulin in men and women. Nutrition. 2010;26:686–693. - PMC - PubMed
1. Guillet C, Boirie Y. Insulin resistance: A contributing factor to age-related muscle mass loss? Diabetes Metab. 2005;31Spec(No 2):5S20–25S26. - PubMed

Association between insulin resistance and lean mass loss and fat mass gain in older men without diabetes mellitus - PubMed (original) (raw)