Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemias - PubMed (original) (raw)
Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemias
L Longo et al. J Exp Med. 1990.
Abstract
Although acute promyelocytic leukemias (APLs) are consistently associated with a reciprocal chromosome 15;17 translocation, the gene(s) directly affected by the breakpoints have never been isolated. The chromosome 17 breakpoint maps to near the retinoic acid receptor alpha (RAR alpha) locus. Investigation of 20 APLs and a large series of other neoplastic patients and normal controls revealed RAR alpha gene rearrangements and aberrant transcripts only in the APL cases. These findings suggest that the RAR alpha gene is involved in the APL chromosome 17 breakpoint, is implicated in leukemogenesis, and could be used as a marker for identifying leukemic promyelocytes.
Similar articles
- Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia.
Chen SJ, Zelent A, Tong JH, Yu HQ, Wang ZY, Derré J, Berger R, Waxman S, Chen Z. Chen SJ, et al. J Clin Invest. 1993 May;91(5):2260-7. doi: 10.1172/JCI116453. J Clin Invest. 1993. PMID: 8387545 Free PMC article. - Translocation breakpoint of acute promyelocytic leukemia lies within the retinoic acid receptor alpha locus.
Alcalay M, Zangrilli D, Pandolfi PP, Longo L, Mencarelli A, Giacomucci A, Rocchi M, Biondi A, Rambaldi A, Lo Coco F, et al. Alcalay M, et al. Proc Natl Acad Sci U S A. 1991 Mar 1;88(5):1977-81. doi: 10.1073/pnas.88.5.1977. Proc Natl Acad Sci U S A. 1991. PMID: 1848017 Free PMC article. - RAR-alpha gene rearrangements as a genetic marker for diagnosis and monitoring in acute promyelocytic leukemia.
Biondi A, Rambaldi A, Alcalay M, Pandolfi PP, Lo Coco F, Diverio D, Rossi V, Mencarelli A, Longo L, Zangrilli D, et al. Biondi A, et al. Blood. 1991 Apr 1;77(7):1418-22. Blood. 1991. PMID: 1849030 - Acute promyelocytic leukaemia and the t(15;17) translocation.
Gillard EF, Solomon E. Gillard EF, et al. Semin Cancer Biol. 1993 Dec;4(6):359-67. Semin Cancer Biol. 1993. PMID: 8142621 Review. - Acute promyelocytic leukemia: from clinic to molecular biology.
Chen SJ, Wang ZY, Chen Z. Chen SJ, et al. Stem Cells. 1995 Jan;13(1):22-31. doi: 10.1002/stem.5530130104. Stem Cells. 1995. PMID: 7719245 Review.
Cited by
- History of Developing Acute Promyelocytic Leukemia Treatment and Role of Promyelocytic Leukemia Bodies.
Bercier P, de Thé H. Bercier P, et al. Cancers (Basel). 2024 Mar 29;16(7):1351. doi: 10.3390/cancers16071351. Cancers (Basel). 2024. PMID: 38611029 Free PMC article. Review. - Obesity accelerates acute promyelocytic leukemia in mice and reduces sex differences in latency and penetrance.
Kincaid JWR, Weiss G, Hill-Baskin AE, Schmidt HM, Omoijuanfo O, Thompson CL, Beck RC, Berger NA. Kincaid JWR, et al. Obesity (Silver Spring). 2022 Jul;30(7):1420-1429. doi: 10.1002/oby.23435. Epub 2022 May 24. Obesity (Silver Spring). 2022. PMID: 35610936 Free PMC article. - History of Acute Promyelocytic Leukemia.
Sanz MA, Barragán E. Sanz MA, et al. Clin Hematol Int. 2021 Jul 19;3(4):142-152. doi: 10.2991/chi.k.210703.001. eCollection 2021 Dec. Clin Hematol Int. 2021. PMID: 34938986 Free PMC article. Review. - Therapeutic Potential of Targeting the SUMO Pathway in Cancer.
Kukkula A, Ojala VK, Mendez LM, Sistonen L, Elenius K, Sundvall M. Kukkula A, et al. Cancers (Basel). 2021 Aug 31;13(17):4402. doi: 10.3390/cancers13174402. Cancers (Basel). 2021. PMID: 34503213 Free PMC article. Review.
References
- Br J Haematol. 1973 Feb;24(2):255-9 - PubMed
- Br J Haematol. 1976 Aug;33(4):451-8 - PubMed
- Lancet. 1977 Mar 5;1(8010):549-50 - PubMed
- Proc Natl Acad Sci U S A. 1980 May;77(5):2936-40 - PubMed
- EMBO J. 1985 Mar;4(3):683-6 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources