Hepatitis C virus in a prospective study of posttransfusion non-A, non-B hepatitis in Taiwan - PubMed (original) (raw)
Hepatitis C virus in a prospective study of posttransfusion non-A, non-B hepatitis in Taiwan
J T Wang et al. J Med Virol. 1990 Oct.
Abstract
Using an enzyme-linked immunosorbant assay for antibody against hepatitis C virus (anti-HCV), serial serum samples from 26 non-A, non-B (NANB) posttransfusion hepatitis (PTH) patients were studied in a prospective study in Taiwan. Sixteen (61.5%) of the 26 patients were positive for anti-HCV antibodies. Two of the 16 patients were positive for anti-HCV before transfusion. The remaining 10 patients were negative for anti-HCV antibodies. The rate of anti-HCV seroconversion is, therefore, 58.5%. Of the 14 patients with anti-HCV seroconversion, three were hepatitis B surface antigen (HBsAg) carriers. The time of seroconversion for anti-HCV ranges from 2 to 24 weeks after the first elevation of ALT (mean: of 8.7 weeks,) or 6-32 weeks from the date of transfusion (mean: 13 weeks). Twelve (85.7%) of the 14 anti-HCV seroconverted patients had persistent abnormal ALT 6 months after the onset of hepatitis in contrast to 30% of chronicity in the anti-HCV-negative patients. The results suggest that HCV is the major causative agent in NANB PTH in Taiwan, and patients positive for anti-HCV have a higher risk of chronicity.
Similar articles
- Minimal role of hepatitis B virus in posttransfusion non-A, non-B hepatitis in Taiwan: a study by polymerase chain reaction.
Wang JT, Sheu JC, Lin JT, Shih LN, Chen DS, Wang TH. Wang JT, et al. J Formos Med Assoc. 1991 May;90(5):471-5. J Formos Med Assoc. 1991. PMID: 1680985 - Seroconversion to hepatitis C virus antibodies in patients with acute posttransfusion non-A, non-B hepatitis in Sweden.
Mattsson L, Grillner L, von Sydow M, Bergdahl S, Weiland O. Mattsson L, et al. Infection. 1991 Sep-Oct;19(5):309-12. doi: 10.1007/BF01645353. Infection. 1991. PMID: 1666063 - Seroconversion to hepatitis C virus antibodies in patients with acute posttransfusion non-A, non-B hepatitis in Sweden with a second generation test.
Mattsson L, Grillner L, Weiland O. Mattsson L, et al. Scand J Infect Dis. 1992;24(1):15-20. doi: 10.3109/00365549209048395. Scand J Infect Dis. 1992. PMID: 1375390 - Non-A, non-B hepatitis and the anti-HCV assay.
Barbara JA, Contreras M. Barbara JA, et al. Vox Sang. 1991;60(1):1-7. doi: 10.1111/j.1423-0410.1991.tb00863.x. Vox Sang. 1991. PMID: 1711260 Review. - Prevalence and significance of anti-HCV antibodies.
De Groote J. De Groote J. Acta Gastroenterol Belg. 1991 May-Aug;54(3-4):248-56. Acta Gastroenterol Belg. 1991. PMID: 1665270 Review.
Cited by
- Hepatitis C virus infection in Lebanese patients with B-cell non-Hodgkin's lymphoma.
Salem Z, Nuwaiyri-Salti N, Ramlawi F, Ramia S. Salem Z, et al. Eur J Epidemiol. 2003;18(3):251-3. doi: 10.1023/A:1023380316098. Eur J Epidemiol. 2003. PMID: 12800950 - Mapping of serotype-specific, immunodominant epitopes in the NS-4 region of hepatitis C virus (HCV): use of type-specific peptides to serologically differentiate infections with HCV types 1, 2, and 3.
Simmonds P, Rose KA, Graham S, Chan SW, McOmish F, Dow BC, Follett EA, Yap PL, Marsden H. Simmonds P, et al. J Clin Microbiol. 1993 Jun;31(6):1493-503. doi: 10.1128/jcm.31.6.1493-1503.1993. J Clin Microbiol. 1993. PMID: 7686182 Free PMC article. - Hepatitis C markers in hemodialysis patients.
Huang CS, Ho MS, Yang CS, Lee CL, Tan CA. Huang CS, et al. J Clin Microbiol. 1993 Jul;31(7):1764-9. doi: 10.1128/jcm.31.7.1764-1769.1993. J Clin Microbiol. 1993. PMID: 7688754 Free PMC article. - Decline in hepatitis B infection in sickle cell anaemia and beta thalassaemia major.
al-Fawaz I, Ramia S. al-Fawaz I, et al. Arch Dis Child. 1993 Nov;69(5):594-6. doi: 10.1136/adc.69.5.594. Arch Dis Child. 1993. PMID: 8257183 Free PMC article. - Mode of hepatitis C virus infection, epidemiology, and chronicity rate in the general population and risk groups.
Tillmann HL, Manns MP. Tillmann HL, et al. Dig Dis Sci. 1996 Dec;41(12 Suppl):27S-40S. doi: 10.1007/BF02087874. Dig Dis Sci. 1996. PMID: 9011473 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical