CRF receptor regulation and sensitization of ACTH responses to acute ether stress during chronic intermittent immobilization stress - PubMed (original) (raw)
CRF receptor regulation and sensitization of ACTH responses to acute ether stress during chronic intermittent immobilization stress
R L Hauger et al. Brain Res. 1990.
Abstract
The relationship between corticotropin releasing factor (CRF) receptors and pituitary-adrenal responses was determined after chronic intermittent immobilization (2.5 h restraint/day) to examine the hypothesis that CRF receptor regulation is involved in the sensitization of the pituitary-adrenocortical axis to novel stimuli during repeated stress. Following the 11-fold stimulation of ACTH secretion on the first day of restraint stress, a desensitization of the pituitary ACTH response to immobilization was observed over the next 9 days of chronic intermittent stress. In contrast, the magnitude of the restraint-stimulated release of corticosterone on the 2nd and 4th day of stress was similar to the day 1 adrenocortical response. Furthermore, the significant stimulation of corticosterone secretion by restraint stress persisted to the 16th day of immobilization (P less than 0.001), even though significant increases in plasma ACTH were absent. The concentration of anterior pituitary CRF receptors was unchanged after a single period of restraint; however, a down-regulation of anterior pituitary CRF receptors was observed following 4 days (P less than 0.001) and 10 days (P less than 0.005) of repeated immobilization stress. CRF receptors in the olfactory bulb were unchanged following acute or chronic restraint stress, consistent with previous observations that brain CRF receptors are neither changed by adrenalectomy, glucocorticoid administration, nor 18-48 h of continuous restraint stress. The concentration of CRF receptors in the intermediate lobe of the pituitary also was not influenced by immobilization stress.(ABSTRACT TRUNCATED AT 250 WORDS)
Similar articles
- Corticotropin-releasing factor receptors and pituitary adrenal responses during immobilization stress.
Hauger RL, Millan MA, Lorang M, Harwood JP, Aguilera G. Hauger RL, et al. Endocrinology. 1988 Jul;123(1):396-405. doi: 10.1210/endo-123-1-396. Endocrinology. 1988. PMID: 2838259 - Desensitization of the hypothalamic-pituitary-adrenal axis following prolonged administration of corticotropin-releasing hormone or vasopressin.
Tizabi Y, Aguilera G. Tizabi Y, et al. Neuroendocrinology. 1992 Nov;56(5):611-8. doi: 10.1159/000126283. Neuroendocrinology. 1992. PMID: 1336816 - Differential regulation of brain and pituitary corticotropin-releasing factor receptors by corticosterone.
Hauger RL, Millan MA, Catt KJ, Aguilera G. Hauger RL, et al. Endocrinology. 1987 Apr;120(4):1527-33. doi: 10.1210/endo-120-4-1527. Endocrinology. 1987. PMID: 3030704 - Receptor-mediated actions of corticotropin-releasing factor in pituitary gland and nervous system.
Aguilera G, Wynn PC, Harwood JP, Hauger RL, Millan MA, Grewe C, Catt KJ. Aguilera G, et al. Neuroendocrinology. 1986;43(1):79-88. doi: 10.1159/000124513. Neuroendocrinology. 1986. PMID: 3012395 Review. - Hypothalamic Regulation of Corticotropin-Releasing Factor under Stress and Stress Resilience.
Kageyama K, Iwasaki Y, Daimon M. Kageyama K, et al. Int J Mol Sci. 2021 Nov 12;22(22):12242. doi: 10.3390/ijms222212242. Int J Mol Sci. 2021. PMID: 34830130 Free PMC article. Review.
Cited by
- The anteroventral bed nucleus of the stria terminalis differentially regulates hypothalamic-pituitary-adrenocortical axis responses to acute and chronic stress.
Choi DC, Evanson NK, Furay AR, Ulrich-Lai YM, Ostrander MM, Herman JP. Choi DC, et al. Endocrinology. 2008 Feb;149(2):818-26. doi: 10.1210/en.2007-0883. Epub 2007 Nov 26. Endocrinology. 2008. PMID: 18039788 Free PMC article. - Stress vulnerability during adolescent development in rats.
Jankord R, Solomon MB, Albertz J, Flak JN, Zhang R, Herman JP. Jankord R, et al. Endocrinology. 2011 Feb;152(2):629-38. doi: 10.1210/en.2010-0658. Epub 2010 Nov 24. Endocrinology. 2011. PMID: 21106877 Free PMC article. - Hypoactivity of the hypothalamo-pituitary-adrenocortical axis during recovery from chronic variable stress.
Ostrander MM, Ulrich-Lai YM, Choi DC, Richtand NM, Herman JP. Ostrander MM, et al. Endocrinology. 2006 Apr;147(4):2008-17. doi: 10.1210/en.2005-1041. Epub 2006 Jan 5. Endocrinology. 2006. PMID: 16396985 Free PMC article. - Evidence for arginine vasopressin as the primary activator of the HPA axis during adjuvant-induced arthritis.
Chowdrey HS, Larsen PJ, Harbuz MS, Jessop DS, Aguilera G, Eckland DJ, Lightman SL. Chowdrey HS, et al. Br J Pharmacol. 1995 Nov;116(5):2417-24. doi: 10.1111/j.1476-5381.1995.tb15089.x. Br J Pharmacol. 1995. PMID: 8581278 Free PMC article. - Brief daily postpartum separations from the litter alter dam response to psychostimulants and to stress.
Silveira PP, Benetti Cda S, Portella AK, Diehl LA, Molle RD, Lucion AB, Dalmaz C. Silveira PP, et al. Braz J Med Biol Res. 2013 May;46(5):426-32. doi: 10.1590/1414-431X20132784. Epub 2013 May 24. Braz J Med Biol Res. 2013. PMID: 23739746 Free PMC article.