Prevalence and progression of monoclonal gammopathy of undetermined significance and light-chain MGUS in Germany - PubMed (original) (raw)
Prevalence and progression of monoclonal gammopathy of undetermined significance and light-chain MGUS in Germany
Lewin Eisele et al. Ann Hematol. 2012 Feb.
Abstract
We determined the prevalence and progression rate of monoclonal gammopathy of undetermined significance (MGUS) and light-chain MGUS (LCMGUS) in Germany utilizing the biobank of the population-based Heinz Nixdorf Recall Study. The Heinz Nixdorf Recall Study comprises 4,814 men and women aged 45-75 years. To detect monoclonal proteins, standard serum electrophoresis was combined with parallel screening immunofixation using pentavalent antisera. Additionally, free light chains (FLC) were measured in all samples. Definition of MGUS included M-protein concentration, laboratory results, and disease history. LCMGUS was defined as abnormal FLC ratio, increase in FLC causing the abnormal ratio, and lack of intact immunoglobulin. One hundred sixty-five MGUS cases were identified among 4,702 screened samples (prevalence 3.5%, 95% confidence interval (CI) 3.0-4.1; median age 63 years, range 47-75 years; 103 (62%) male; IgG 59%, IgA 17%, IgM 17%, biclonal 4.8%, kappa 56%, and lambda 44%). Five cases progressed (0.6%/year, 95% CI 0.2-1.4). An abnormal FLC ratio was detected in 220 samples. Thirty-nine of these showed intact immunoglobulin. Thirty-four of the remaining met LCMGUS criteria (prevalence 0.7%, 95% CI 0.5-1.0). None of the LCMGUS cases progressed. We demonstrate a MGUS prevalence of 3.5% and a LCMGUS prevalence of 0.7% in the general population aged 45-75 years in Germany using a sensitive screening approach.
Similar articles
- Light chain monoclonal gammopathy of undetermined significance is characterized by a high disappearance rate and low risk of progression on longitudinal analysis.
Pelzer BW, Arendt M, Moebus S, Eisele L, Jöckel KH, Dührsen U, Dürig J; Heinz Nixdorf Recall Study Investigative Group. Pelzer BW, et al. Ann Hematol. 2018 Aug;97(8):1463-1469. doi: 10.1007/s00277-018-3305-x. Epub 2018 Apr 9. Ann Hematol. 2018. PMID: 29629484 - Presence of monoclonal free light chains in the serum predicts risk of progression in monoclonal gammopathy of undetermined significance.
Rajkumar SV, Kyle RA, Therneau TM, Clark RJ, Bradwell AR, Melton LJ 3rd, Larson DR, Plevak MF, Katzmann JA. Rajkumar SV, et al. Br J Haematol. 2004 Nov;127(3):308-10. doi: 10.1111/j.1365-2141.2004.05169.x. Br J Haematol. 2004. PMID: 15491291 - Prevalence of monoclonal gammopathy of undetermined significance in an elderly urban Korean population.
Park HK, Lee KR, Kim YJ, Cho HI, Eun Kim J, Woong Kim K, Jung Kim Y, Lee KW, Hyun Kim J, Bang SM, Lee JS. Park HK, et al. Am J Hematol. 2011 Sep;86(9):752-5. doi: 10.1002/ajh.22095. Epub 2011 Jul 22. Am J Hematol. 2011. PMID: 21786289 - [Monoclonal gammopathy of undetermined significance].
Chaïbi P, Merlin L, Thomas C, Piette F. Chaïbi P, et al. Ann Med Interne (Paris). 2002 Nov;153(7):459-66. Ann Med Interne (Paris). 2002. PMID: 12598832 Review. French. - Monoclonal gammopathy of undetermined significance and smouldering multiple myeloma: emphasis on risk factors for progression.
Kyle RA, Rajkumar SV. Kyle RA, et al. Br J Haematol. 2007 Dec;139(5):730-43. doi: 10.1111/j.1365-2141.2007.06873.x. Br J Haematol. 2007. PMID: 18021088 Review.
Cited by
- Associated conditions in small fiber neuropathy - a large cohort study and review of the literature.
de Greef BTA, Hoeijmakers JGJ, Gorissen-Brouwers CML, Geerts M, Faber CG, Merkies ISJ. de Greef BTA, et al. Eur J Neurol. 2018 Feb;25(2):348-355. doi: 10.1111/ene.13508. Epub 2017 Dec 18. Eur J Neurol. 2018. PMID: 29112785 Free PMC article. Review. - Paraprotein interference with turbidimetric gentamicin assay.
Dimeski G, Bassett K, Brown N. Dimeski G, et al. Biochem Med (Zagreb). 2015;25(1):117-24. doi: 10.11613/BM.2015.014. Biochem Med (Zagreb). 2015. PMID: 25672475 Free PMC article. - Relationship between circulating syndecan-1 levels (CD138s) and serum free light chains in monoclonal gammopathies.
Cigliana G, Torti E, Gulli F, De Santis E, Dell'Abate MT, Colacicco L, Pisani F, Conti L, Basile U. Cigliana G, et al. J Exp Clin Cancer Res. 2015 Apr 23;34(1):37. doi: 10.1186/s13046-015-0155-4. J Exp Clin Cancer Res. 2015. PMID: 26025441 Free PMC article. - Immune defects in the risk of infection and response to vaccination in monoclonal gammopathy of undetermined significance and multiple myeloma.
Tete SM, Bijl M, Sahota SS, Bos NA. Tete SM, et al. Front Immunol. 2014 Jun 3;5:257. doi: 10.3389/fimmu.2014.00257. eCollection 2014. Front Immunol. 2014. PMID: 24917865 Free PMC article. Review. - Schnitzler syndrome: an under-diagnosed clinical entity.
Jain T, Offord CP, Kyle RA, Dingli D. Jain T, et al. Haematologica. 2013 Oct;98(10):1581-5. doi: 10.3324/haematol.2013.084830. Epub 2013 Jun 28. Haematologica. 2013. PMID: 23812931 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous