Mononuclear phagocyte heterogeneity in cancer: different subsets and activation states reaching out at the tumor site - PubMed (original) (raw)

Review

. 2011 Nov;216(11):1192-202.

doi: 10.1016/j.imbio.2011.06.007. Epub 2011 Jun 30.

Affiliations

• PMID: 21803441
• DOI: 10.1016/j.imbio.2011.06.007

Review

Mononuclear phagocyte heterogeneity in cancer: different subsets and activation states reaching out at the tumor site

Damya Laoui et al. Immunobiology. 2011 Nov.

Abstract

Mononuclear phagocytes are amongst the most versatile cells of the body, contributing to tissue genesis and homeostasis and safeguarding the balance between pro- and anti-inflammatory reactions. Accordingly, these cells are notoriously heterogeneous, functioning in distinct differentiation forms (monocytes, MDSC, macrophages, DC) and adopting different activation states in response to a changing microenvironment. Accumulating evidence exists that mononuclear phagocytes contribute to all phases of the cancer process. These cells orchestrate the inflammatory events during de novo carcinogenesis, participate in tumor immunosurveillance, and contribute to the progression of established tumors. At the tumor site, cells such as tumor-associated macrophages (TAM) are confronted with different tumor microenvironments, leading to TAM subsets with specialized functions. A better refinement of the molecular and functional heterogeneity of tumor-associated mononuclear phagocytes might pave the way for novel cancer therapies that directly target these tumor-supporting cells.

Copyright © 2011 Elsevier GmbH. All rights reserved.

PubMed Disclaimer

Similar articles

• The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance.
  Allavena P, Sica A, Garlanda C, Mantovani A. Allavena P, et al. Immunol Rev. 2008 Apr;222:155-61. doi: 10.1111/j.1600-065X.2008.00607.x. Immunol Rev. 2008. PMID: 18364000 Review.
• Classical and alternative activation of mononuclear phagocytes: picking the best of both worlds for tumor promotion.
  Van Ginderachter JA, Movahedi K, Hassanzadeh Ghassabeh G, Meerschaut S, Beschin A, Raes G, De Baetselier P. Van Ginderachter JA, et al. Immunobiology. 2006;211(6-8):487-501. doi: 10.1016/j.imbio.2006.06.002. Epub 2006 Jul 21. Immunobiology. 2006. PMID: 16920488 Review.
• The multi-faceted roles of prostaglandin E2 in cancer-infiltrating mononuclear phagocyte biology.
  Sha W, Brüne B, Weigert A. Sha W, et al. Immunobiology. 2012 Dec;217(12):1225-32. doi: 10.1016/j.imbio.2012.05.001. Epub 2012 May 11. Immunobiology. 2012. PMID: 22727331 Review.
• A glimpse on the phenomenon of macrophage polarization during atherosclerosis.
  Pello OM, Silvestre C, De Pizzol M, Andrés V. Pello OM, et al. Immunobiology. 2011 Nov;216(11):1172-6. doi: 10.1016/j.imbio.2011.05.010. Epub 2011 May 24. Immunobiology. 2011. PMID: 21802768 Review.
• Tumor-associated macrophages in breast cancer: distinct subsets, distinct functions.
  Laoui D, Movahedi K, Van Overmeire E, Van den Bossche J, Schouppe E, Mommer C, Nikolaou A, Morias Y, De Baetselier P, Van Ginderachter JA. Laoui D, et al. Int J Dev Biol. 2011;55(7-9):861-7. doi: 10.1387/ijdb.113371dl. Int J Dev Biol. 2011. PMID: 22161841 Review.

Cited by

• Prognostic value of intratumoral lymphocyte-to-monocyte ratio and M0 macrophage enrichment in tumor immune microenvironment of melanoma.
  Jairath NK, Farha MW, Jairath R, Harms PW, Tsoi LC, Tejasvi T. Jairath NK, et al. Melanoma Manag. 2020 Nov 2;7(4):MMT51. doi: 10.2217/mmt-2020-0019. Melanoma Manag. 2020. PMID: 33318782 Free PMC article.
• Pigment epithelium-derived factor, an anti-VEGF factor, delays ovarian cancer progression by alleviating polarization of tumor-associated macrophages.
  Ma R, Chu X, Jiang Y, Xu Q. Ma R, et al. Cancer Gene Ther. 2022 Oct;29(10):1332-1341. doi: 10.1038/s41417-022-00447-4. Epub 2022 Mar 4. Cancer Gene Ther. 2022. PMID: 35246611
• Characterization of the Tumor Immune Microenvironment Identifies M0 Macrophage-Enriched Cluster as a Poor Prognostic Factor in Hepatocellular Carcinoma.
  Farha M, Jairath NK, Lawrence TS, El Naqa I. Farha M, et al. JCO Clin Cancer Inform. 2020 Oct;4:1002-1013. doi: 10.1200/CCI.20.00077. JCO Clin Cancer Inform. 2020. PMID: 33136432 Free PMC article.
• Imaging interactions between macrophages and tumour cells that are involved in metastasis in vivo and in vitro.
  Dovas A, Patsialou A, Harney AS, Condeelis J, Cox D. Dovas A, et al. J Microsc. 2013 Sep;251(3):261-9. doi: 10.1111/j.1365-2818.2012.03667.x. Epub 2012 Nov 30. J Microsc. 2013. PMID: 23198984 Free PMC article. Review.
• Single cell RNA-Sequencing Reveals Mast Cells Enhance Mononuclear Phagocytes Infiltration in Bladder Cancer Microenvironment.
  Liu Z, Huang C, Mao X, Mi J, Zhang Q, Xie Y, Yuan H, Jili M, Zhang J, Chen J, Huang S, Mo Z, Yang R. Liu Z, et al. J Cancer. 2024 Sep 3;15(17):5672-5690. doi: 10.7150/jca.99554. eCollection 2024. J Cancer. 2024. PMID: 39308672 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • ClinicalKey
  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database