The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease - PubMed (original) (raw)

. 2011 Aug 5;11(9):607-15.

doi: 10.1038/nri3041.

Affiliations

• PMID: 21818123
• DOI: 10.1038/nri3041

The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease

Michael Gleeson et al. Nat Rev Immunol. 2011.

Abstract

Regular exercise reduces the risk of chronic metabolic and cardiorespiratory diseases, in part because exercise exerts anti-inflammatory effects. However, these effects are also likely to be responsible for the suppressed immunity that makes elite athletes more susceptible to infections. The anti-inflammatory effects of regular exercise may be mediated via both a reduction in visceral fat mass (with a subsequent decreased release of adipokines) and the induction of an anti-inflammatory environment with each bout of exercise. In this Review, we focus on the known mechanisms by which exercise - both acute and chronic - exerts its anti-inflammatory effects, and we discuss the implications of these effects for the prevention and treatment of disease.

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